| Identification | Back Directory | [Name]
DDD85646 | [CAS]
1215010-55-1 | [Synonyms]
DDD85646
DDD 85646
(DDD85646)
DDD85646 Hydrochloride
Benzenesulfonamide, 2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-
African trypanosomiasis,N-myristoyltransferase,inhibit,DDD85646,Inhibitor,trypanosoma brucei,DNA/RNA Synthesis,NMT,Parasite | [Molecular Formula]
C21H24Cl2N6O2S | [MOL File]
1215010-55-1.mol | [Molecular Weight]
495.43 |
| Chemical Properties | Back Directory | [Melting point ]
>215°C (dec.) | [Boiling point ]
684.3±65.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly) | [form ]
Solid | [pka]
7.04±0.50(Predicted) | [color ]
Off-White to Yellow |
| Hazard Information | Back Directory | [Description]
DDD85646 is a moderately bioavailable pyrazole sulphonamide inhibitor of T. brucei N-myristoyltransferase (TbNMT) with an apparent Ki value of 1.44 nM. T. brucei is the parasite responsible for human African trypanosomiasis (HAT), also known as African sleeping sickness, and is transmitted through the tsetse fly. DDD85646 administration in mice (12.5 mg/kg for four days) ameliorated T. brucei in an acute mouse model of HAT. It less potently inhibits growth of T. cruzi (EC50 = 6.9 μM). | [Uses]
DDD85646 is a potent inhibitor of Trypanosoma brucei N-myristoyltransferase (TbNMT). | [storage]
Store at -20°C |
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