Identification | Back Directory | [Name]
USP7-IN-1 | [CAS]
1381291-36-6 | [Synonyms]
USP7i-1 USP7-IN-1 USP7 inhibitor 1 Inhibitor,inhibit,USP-7-IN-1,USP7IN1,USP7 IN 1,DUBs,Deubiquitinase 4(3H)-Quinazolinone, 7-chloro-3-[[4-hydroxy-1-(1-oxo-3-phenylpropyl)-4-piperidinyl]methyl]- | [Molecular Formula]
C23H24ClN3O3 | [MOL File]
1381291-36-6.mol | [Molecular Weight]
425.91 |
Hazard Information | Back Directory | [Description]
USP7-IN-1 is a selective and reversible inhibitor of ubiquitin-specific protease 7 (USP7), with an IC50 of 77 μM, and can be used for the research of cancer.
IC50: 77 μM (USP7)[1]USP7-IN-1 (Example 2) is a selective and reversible inhibitor of USP7, with an IC50 of 77 μM, and shows no inhibition of USP8, USP5, Uch-L1, Uch-L3 or caspase 3. USP7-IN-1 inhibits the proliferation of HCT116 cells, with a GI50 of 67 μM[1]. | [References]
[1]. SELECTIVE AND REVERSIBLE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7. WO 2013030218 A1 |
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