| Identification | Back Directory | [Name]
5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE | [CAS]
145915-60-2 | [Synonyms]
DAPH 2
DAPH-7
CGP 53353
CGP-53353 solid
PKCβII/EGFR Inhibitor - CAS 145915-60-2 - Calbiochem
5,6-BIS[(4-FLUOROPHENYL)AMINO]-2H-ISOINDOLE-1,3-DIONE
5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]-
5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione, DAPH 2 | [Molecular Formula]
C20H13F2N3O2 | [MDL Number]
MFCD00938569 | [MOL File]
145915-60-2.mol | [Molecular Weight]
365.33 |
| Hazard Information | Back Directory | [Uses]
CGP 53353 inhibited tyrosine kinase activity of the EGF-R in five different human transitional cell carcinoma lines. | [Definition]
ChEBI: 5,6-bis(4-fluoroanilino)isoindole-1,3-dione is a member of phthalimides. | [Biological Activity]
Selective inhibitor of PKC β II (IC 50 values are 0.41 and 3.8 μ M for PKC β II and PKC β I respectively). Also inhibits prionogenic Sup35 fibrillization (IC 50 ~ 3.4 μ M) and inhibits de novo A β 42 assembly in vitro . | [storage]
Store at RT |
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