| Identification | Back Directory | [Name]
TCO-PEG4-NHS ester | [CAS]
1613439-69-2 | [Synonyms]
TCO-PEG4-NHS ester
(4E)-TCO-PEG4-NHS ester
(Z)-2,5-dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate
5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(4-cycloocten-1-yl) 17-(2,5-dioxo-1-pyrrolidinyl) ester | [Molecular Formula]
C24H38N2O10 | [MDL Number]
MFCD28118912 | [MOL File]
1613439-69-2.mol | [Molecular Weight]
514.57 |
| Chemical Properties | Back Directory | [density ]
1.23±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [pka]
11.95±0.46(Predicted) | [InChI]
InChI=1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h1-2,20H,3-19H2,(H,25,30)/b2-1- | [InChIKey]
ZKPMRASGLDBKPF-UPHRSURJSA-N | [SMILES]
C(OC1CCCC=CCC1)(=O)NCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O |c:6| |
| Hazard Information | Back Directory | [Description]
TCO-PEG4-NHS Ester is a click chemistry crosslinker. This reagent can be used to label antibodies, proteins and other primary amine containing molecule. The hydrophilic PEG spacer increases water-solubility and decreases steric hindrance during ligation. TCO enable fast click chemistry under mild condition | [Biological Activity]
TCO-PEG4-NHS ester is a PROTAC linker and belongs to the PEG class,it can be used to synthesize a series of PROTAC molecules.It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | [in vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
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