| Identification | Back Directory | [Name]
Cholan-24-oic acid, 3,7-dihydroxy-, MonosodiuM salt, (3a,5b,7b)- | [CAS]
2898-95-5 | [Synonyms]
Sodium ursodesoxycholate
URSODEOXYCHOLIC ACID SODIUM SALT USP/EP/BP
Cholan-24-oic acid, 3,7-dihydroxy-, MonosodiuM salt, (3a,5b,7b)-
(3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-oic acid monosodium salt | [Molecular Formula]
C24H39NaO4 | [MOL File]
2898-95-5.mol | [Molecular Weight]
414.554 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 5 mg/ml; DMSO: 10 mg/ml; Ethanol: 15 mg/ml | [form ]
A crystalline solid | [InChIKey]
WDFRNBJHDMUMBL-LEMNXDLSNA-M | [SMILES]
[Na+].[C@H]1(O)C[C@]2([H])[C@](C)(CC1)C1C(C3[C@@](CC1)(C)[C@@H]([C@H](C)CCC([O-])=O)CC3)[C@@H](O)C2 |&1:1,4,6,13,17,18,27,r| |
| Hazard Information | Back Directory | [Description]
Ursodeoxycholic acid (UDCA) is a secondary bile acid formed via epimerization of chenodeoxycholic acid (CDCA; Item No. 10011286).1,2 UDCA is also a metabolite of lithocholic acid (LCA; Item No. 20253) in human liver microsomes.3 It inhibits taurocholic acid (Item No. 16215) uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC50 value of 3.6 μM.4 UDCA (50 μM) inhibits apoptosis induced by deoxycholic acid (DCA; Item Nos. 20756 | 18231) or ethanol in primary rat hepatocytes.5 Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis. |
| Spectrum Detail | Back Directory | [Spectrum Detail]
Cholan-24-oic acid, 3,7-dihydroxy-, MonosodiuM salt, (3a,5b,7b)-(2898-95-5)1HNMR
Cholan-24-oic acid, 3,7-dihydroxy-, MonosodiuM salt, (3a,5b,7b)-(2898-95-5)13CNMR
Cholan-24-oic acid, 3,7-dihydroxy-, MonosodiuM salt, (3a,5b,7b)-(2898-95-5)IR1
Cholan-24-oic acid, 3,7-dihydroxy-, MonosodiuM salt, (3a,5b,7b)-(2898-95-5)IR2
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