Identification | Back Directory | [Name]
Thioproperazine | [CAS]
316-81-4 | [Synonyms]
Vontil Majeptyl Mazeptyl Megeptil Cephalmin Sulfenazin hioproperazine thioproperazine N'-(4-chlorophenyl)-N,N-dimethylcarbamimidic acid methyl ester N,N-Dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide Phenothiazine-2-sulfonamide, N,N-dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]- 10H-Phenothiazine-2-sulfonamide, N,N-dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]- | [EINECS(EC#)]
206-262-4 | [Molecular Formula]
C22H30N4O2S2 | [MDL Number]
MFCD00867741 | [MOL File]
316-81-4.mol | [Molecular Weight]
446.63 |
Chemical Properties | Back Directory | [Melting point ]
140° | [Boiling point ]
612.2±65.0 °C(Predicted) | [density ]
1.1476 (rough estimate) | [refractive index ]
1.6200 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
7.65±0.10(Predicted) | [NIST Chemistry Reference]
|
Hazard Information | Back Directory | [Originator]
Majeptil,Specia,France,1960 | [Definition]
ChEBI: A phenothiazine derivative in which the phenothiazine tricycle has a dimethylaminosulfonyl substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at N-10. | [Manufacturing Process]
A solution of 3-dimethylsulfamoylphenthiazine (5 g) in anhydrous xylene (100
cc) is heated under reflux for 1 hour with sodamide (0.67 g). 3-(4-methyl-1-
piperazinyl)-1-chloropropane (3.2 g) in solution in anhydrous xylene (20 cc) is
added and the mixture heated under reflux for 5 hours. After treatment of the
reaction products, a crude oily base (2.5 g) is obtained after treatment. By
the addition of a solution of fumaric acid in ethanol to an ethanolic solution of
the base, 3-dimethylsulfamoyl-10-(3-41-methyl-11-piperazinylpropyl)-
phenthiazinediacid fumarate (2.6 g) is obtained, melting point 182°C. The
base recrystallized from ethyl acetate melts at about 140°C. | [Therapeutic Function]
Neuroleptic, Antiemetic |
|
Company Name: |
|
Tel: |
+86 (0) 571 85 58 67 18 |
Website: |
www.capotchem.com |
Company Name: |
|
Tel: |
13681854265 |
Website: |
//www.moenpharm.com |
Company Name: |
|
Tel: |
021-60441077 18701958033 |
Website: |
//www.shzxchem.com |
Company Name: |
|
Tel: |
025-66113011 18112977050 |
Website: |
//www.aikonchem.com |
Company Name: |
|
Tel: |
|
Website: |
//www.bocsci.com |
Company Name: |
|
Tel: |
021-58461859 15821823057 |
Website: |
//www.aivichem.com |
Company Name: |
|
Tel: |
400-1647117 15221909166 |
Website: |
www.bidepharm.com/ |
Company Name: |
|
Tel: |
15229059051 |
Website: |
//www.dideu.cn |
Company Name: |
|
Tel: |
4008200310 |
Website: |
//www.targetmol.cn/ |
|