| Identification | Back Directory | [Name]
CARBACYCLIN | [CAS]
69552-46-1 | [Synonyms]
CPGI
Carba pgx
Carba-PGI2
CARBACYCLIN
Carbacycline
6A-Carba-pgi2
CARBACYCLIC PGI2
6,9-Methano pgi2
6,9-Methano-pgi2
CARBOCYCLIC PGI2
CARBOCYCLIC PGL2
carboprostacyclin
CARBAPROSTACYCLIN
6A-CARBA-PROSTAGLANDIN I2
6,9-Methanoprostaglandin I2
(5E)-6a-Carbaprostaglandin 12
(5E)-6A-Carba-prostaglandin I2
Carbacyclin (Carbocyclic PGI2)
9alpha-Deoxy-9alpha-methylene-pgi2
6a-Carba-prostaglandinI2, CarbocyclicPGI2
6,9ALPHA-METHYLENE-11ALPHA,15S-DIHYDROXY-PROSTA-5E,13E-DIEN-1-OIC ACID
5-[(1β,3E,5β,6R)-6β-[(1E,3S)-3-Hydroxy-1-octenyl]-7α-hydroxybicyclo[3.3.0]octane-3-ylidene]pentanoic acid
5-[(2E,3aS,5R,6aβ)-Octahydro-5α-hydroxy-4β-[(1E,3S)-3-hydroxy-1-octenyl]pentalen-2-ylidene]pentanoic acid
Pentanoic acid,5-[(3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-1-octenyl]-2(1H)-pentalenylidene]-,(5E)- | [EINECS(EC#)]
636-209-4 | [Molecular Formula]
C21H34O4 | [MDL Number]
MFCD00210824 | [MOL File]
69552-46-1.mol | [Molecular Weight]
350.49 |
| Chemical Properties | Back Directory | [Melting point ]
65-67℃ | [Boiling point ]
514.8±50.0 °C(Predicted) | [density ]
1.177±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
Soluble at 20mg/ml in ethanol. | [form ]
Solid | [pka]
4.77±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Carbacyclin is a stable analog of PGI2. When infused in rabbits or dogs, it inhibits ex vivo platelet aggregation, but the effect persists only 10 minutes after termination of the infusion. Carbacyclin is a stable analog of PGI2. Carbacyclin inhibits platelet aggregation with 10% of the molar potency exhibited by PGI2. The ED50 of Carbacyclin for the in vitro inhibition of ADP-induced platelet aggregation in human PRP is 47 nM. It was also shown to effect terminal differentiation of preadipose into adipose cells and enhance the expression of angiotensinogen and adipose fatty acid binding protein with an EC50 of about 0.5 μM.
| [Definition]
ChEBI:Carbaprostacyclin is a prostanoid. | [storage]
Store at -20°C |
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