Identification | Back Directory | [Name]
LEUKOTRIENE D4 | [CAS]
73836-78-9 | [Synonyms]
LTD4 leukotriened LEUKOTRIENE D4 leukotriened(sub4) LTD4 (Leukotriene D4) (r-(r*,s*-(e,e,z,z)))-inyl) YEESKJGWJFYOOK-IJHYULJSSA-N LEUKOTRIENE D4 (ETHANOL SOLUTION) 5S-HYDROXY-6R-(S-CYSTEINYLGLYCINYL)-7E,9E,11Z,14Z-EICOSATETRAENOIC ACID glycine,n-(s-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-l-cyste 5(S)-HYDROXY-6(R)-S-CYSTEINYLGLYCINYL-7-TRANS-9-TRANS-11-CIS-14-CIS-EICOSATETRAENOIC ACID S-[(1R,2E,4E,6Z,9Z)-1-[(S)-4-Carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetren-1-yl]-L-Cys-Gly-OH N-[S-[(1R,2E,4E,6Z,9Z)-1-[(S)-4-Carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetren-1-yl]-L-cysteinyl]glycine N-[S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-1-Hydroxy-4-carboxybutyl]-2,4,6,9-pentadecatetren-1-yl]-L-cysteinyl]glycine Glycine, S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-L-cysteinyl- N-[S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-1-Hydroxy-4-carboxybutyl]-2,4,6,9-pentadecatetraene-1-yl]-L-cysteinyl]glycine (5S,6R,7E,9E,11E,14E)-6-[2-amino-2-(carboxymethylcarbamoyl)ethyl]sulfanyl-5-hydroxy-icosa-7,9,11,14-tetraenoic acid | [Molecular Formula]
C25H40N2O6S | [MDL Number]
MFCD00036839 | [MOL File]
73836-78-9.mol | [Molecular Weight]
496.66 |
Chemical Properties | Back Directory | [Boiling point ]
785.8±60.0 °C(Predicted) | [density ]
1.162±0.06 g/cm3(Predicted) | [Fp ]
9℃ | [storage temp. ]
-70°C | [solubility ]
A solution in ethanol | [form ]
Liquid. | [pka]
3.03±0.10(Predicted) |
Hazard Information | Back Directory | [Description]
Leukotriene D4 (LTD4) is an active metabolite of LTC4 (Item Nos. 20210 | 10007241) and a constituent of slow-reacting substance of anaphylaxis (SRS-A). It is formed via metabolism of LTC4 by γ-glutamyl transpeptidase. Like LTC4, LTD4 (0.01-0.1 pM) induces contractions in isolated guinea pig parenchymal strips and tracheal spirals. In vivo, LTD4 increases insufflation pressure, a marker of bronchoconstriction, in anesthetized guinea pigs by 100% when administered at a dose of 89 pmol per animal. It also increases vascular permeability in guinea pig skin when administered intradermally at a dose of 0.1 pmol per animal. | [Uses]
LTD4 (Leukotriene D4) is a member of the leukotriene family shown to be a potent contractor of smooth muscle. | [Definition]
ChEBI: A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and a L-cysteinylglycinyl group at
position 6 (6R). | [Biochem/physiol Actions]
Slow reacting substance of anaphylaxis (SRS-A). Potent bronchoconstrictor and mediator of asthmatic and inflammatory processes. Increases cytosolic free Ca2+ in epithelial cells. | [storage]
Store at -80°C |
|
Company Name: |
|
Tel: |
18521735133 18521732826; |
Website: |
//www.aladdin-e.com/ |
Company Name: |
|
Tel: |
020-39119399 18927568969 |
Website: |
//www.isunpharm.com |
Company Name: |
|
Tel: |
021-61415566 800-8193336 |
Website: |
//www.sigmaaldrich.cn |
Company Name: |
|
Tel: |
021-65675885 18964387627 |
Website: |
//www.efebio.com |
Company Name: |
|
Tel: |
400-9205774 |
Website: |
www.glpbio.cn |
Company Name: |
|
Tel: |
18818260767 |
Website: |
www.chemegen.com |
Company Name: |
|
Tel: |
021-58432009 400-005-6266 |
Website: |
//www.energy-chemical.com |
Company Name: |
|
Tel: |
18768175414 |
Website: |
//www.univ-bio.com/ |
Company Name: |
|
Tel: |
021-34661275 15301693058 |
Website: |
www.yajimall.com/ |
Company Name: |
|
Tel: |
18626450290 |
Website: |
//www.aikonchem.com |
Company Name: |
|
Tel: |
021-50706066 15221275939 |
Website: |
//www.macklin.cn/ |
Company Name: |
|
Tel: |
0513-66337626 18051384581 |
Website: |
//www.chemhifuture.com/ |
Company Name: |
|
Tel: |
(800) 364-9897 |
Website: |
www.caymanchem.com |
Company Name: |
|
Tel: |
+91-22-45045900 |
Website: |
www.clearsynth.com |
Company Name: |
|
Tel: |
800.520.3011 or 781.639.5092 |
Website: |
www.usbio.net |
|