ChemicalBook >> CAS DataBase List >>3-Indolepropionic acid
3-Indolepropionic acid
- CAS No.
- 830-96-6
- Chemical Name:
- 3-Indolepropionic acid
- Synonyms
- PROPAN-2-OL;INDOLE-3-PROPIONIC ACID;3-(1H-INDOL-3-YL)PROPANOIC ACID;ISOPROPANE;ISOPROPYL ALCOHO;ISOPROPANOL ALCOHOL;INDOLEPROPIONIC ACID;2-PPROPANOL;FEMA 2929;ISOPROPANO
- CBNumber:
- CB1183728
- Molecular Formula:
- C11H11NO2
- Molecular Weight:
- 189.21
- MDL Number:
- MFCD00005660
- MOL File:
- 830-96-6.mol
- MSDS File:
- SDS
Last updated:2024-09-06 17:45:48
Melting point | ~133 °C |
---|---|
Boiling point | 82 °C(lit.) |
Density | 0.960 g/mL at 20 °C |
vapor density | 2.1 (vs air) |
vapor pressure | 33 mm Hg ( 20 °C) |
refractive index |
n |
Flash point | 53 °F |
storage temp. | Sealed in dry,Room Temperature |
solubility | ethanol: soluble50mg/mL, clear, yellow to orange |
pka | 4.77±0.10(Predicted) |
form | crystalline |
color | light yellow |
Water Solubility | slightly soluble |
BRN | 147733 |
CAS DataBase Reference | 830-96-6(CAS DataBase Reference) |
EWG's Food Scores | |
FDA UNII | |
NIST Chemistry Reference | |
EPA Substance Registry System |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 22-36/37/38 | |||||||||
Safety Statements | 26-37/39 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | NM1329000 | |||||||||
F | 8-10-23 | |||||||||
TSCA | Yes | |||||||||
HS Code | 29339990 | |||||||||
Toxicity | LDLo intraperitoneal in mouse: 100mg/kg | |||||||||
NFPA 704 |
|
3-Indolepropionic acid price More Price(39)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 57410 | Indole-3-propionic acid ≥97.0% (T) | 830-96-6 | 25g | $116 | 2025-03-01 | Buy |
Sigma-Aldrich | 57410 | Indole-3-propionic acid ≥97.0% (T) | 830-96-6 | 100g | $208 | 2025-03-01 | Buy |
Sigma-Aldrich | 220027 | 3-Indolepropionic acid ReagentPlus , 99% | 830-96-6 | 1g | $30.7 | 2025-03-01 | Buy |
Sigma-Aldrich | 57400 | Indole-3-propionic acid ≥99.0% (T) | 830-96-6 | 5G | $109 | 2025-03-01 | Buy |
Sigma-Aldrich | 220027 | 3-Indolepropionic acid ReagentPlus , 99% | 830-96-6 | 10g | $89.7 | 2025-03-01 | Buy |
3-Indolepropionic acid Chemical Properties,Uses,Production
Description
Indole-3-propionic acid is a bacterial metabolite that has antioxidant and neuroprotective activities. It scavenges ABTS radicals in a cell-free assay when used at concentrations ranging from 50 to 150 μM and decreases hydrogen peroxide-induced malondialdehyde (MDA) levels in rat striatal membranes (IC50 = 180 μM). Indole-3-propionic acid also decreases increases in MDA levels induced by amyloid β (1-42) in PC12 cells. It decreases ischemia-induced increases in cell death of pyramidal neurons and levels of 4-hydroxy nonenal (HNE; ) and glial fibrillary acidic protein (GFAP) in the hippocampal CA1 region in gerbils when administered at a dose of 10 mg/kg per day.
Chemical Properties
pale yellow to yellow crystalline powderUses
Reactant for preparation of:
- Fluorescent analogues of strigolactones
- Anti-tumor agents
- Melanocortin receptors ligands
- Immunosuppressive agents
- Iinhibitors of hepatitis C virus
- Histamine H4 receptor agonists
- NR2B/NMDA receptor antagonists
- CB1 antagonist for the treatment of obesity
- Antibacterial agents
- Inhibitor of TGF-β receptor binding
Uses
3-Indolepropionic acid is a deamination product of Tryptophan (T947200) that protects the hippocampus (studied in gerbils) from ischemic damage and oxidative stress. It’s ability to protect the neurons in this way is attributed to its potent antioxidative effects. 3-Indolepropionic acid is also hypothesized to have protective effects on the thyroid gland.Definition
ChEBI: An indol-3-yl carboxylic acid that is propionic acid substituted by a 1H-indol-3-yl group at position 3.Synthesis Reference(s)
Tetrahedron Letters, 25, p. 3159, 1984 DOI:
General Description
3-Indolepropionic acid is an effective inhibitor of aggregation of misfolded β-amyloid protein (Abeta). Three-component one-pot procedure has been reported to assemble 3-indolepropionic acids.Biochem/physiol Actions
Studied as an adjunct to improve perfusion after liver transplant.Purification Methods
Recrystallise it from EtOH/water [James & Ware J Phys Chem 89 5450 1985]. The picrate has m 143-144o, and the methyl ester crystallises from *C6H6 or MeOH with m 81-83o. [Beilstein 22 III/IV 1113, 22/3 V 114.]3-Indolepropionic acid Preparation Products And Raw materials
Raw materials
1H-Indole-3-propanoic acid, 1-(2,2-dimethyl-1-oxopropyl)-
2-(1H-indol-3-yl)butanedioic acid
1H-Indole-3-propanoic acid, β-oxo-
Diethyl 2-(1H-indol-3-ylmethyl)propanedioate
Propanedioic acid,2-(1H-indol-3-ylmethyl)-
1of4
Preparation Products
Global( 681)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
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career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
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Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
View Lastest Price from 3-Indolepropionic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-06 | 3-Indolepropionic acid
830-96-6
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | ||
2024-06-15 | 3-Indolepropionic acid
830-96-6
|
US $196.00 / KG | 1KG | 98% | 1-20mt | Baoji Guokang Bio-Technology Co., Ltd. | ||
2024-01-06 | 3-Indolepropionic acid
830-96-6
|
US $0.00-0.00 / KG | 1KG | 98.0% | 500kg/month | WUHAN FORTUNA CHEMICAL CO., LTD |
- 3-Indolepropionic acid
830-96-6
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
- 3-Indolepropionic acid
830-96-6
- US $196.00 / KG
- 98%
- Baoji Guokang Bio-Technology Co., Ltd.
- 3-Indolepropionic acid
830-96-6
- US $0.00-0.00 / KG
- 98.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
830-96-6(3-Indolepropionic acid)Related Search:
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3-(1H-INDOL-3-YL)-PROPIONIC ACID
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Ipa (auxin)
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ALCOHOL ISOPROPYL USP ANYHDROUS
ISO PRORYL ALCOHOL
ISO PROPYLE ALCOHOL
Ethyl #niso-nicotinate
INDOLE-3-PROPIONIC ACID PLANT CELL*CULTU RE TESTED
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Indole-3-PropionicAcidForBiochemistry
INDOL33YLPROPIONICACID
3-(Indol-3-yl)propanoic acid
IPA (Isopropyl Alcohol), 70% v/v
ISOPROPYL LACOHOL
ISO PROPYL ALCOHOL ( IPA )
3-(indol-3-yl)propionic acid
1h-indole-3-propanoicacid
1H-Indole-3-propionic acid
1h-indole-3-propionicacid
3-(2-Carboxyethyl)-1H-indole
3-(3-Indole)propionic acid
3-(3-Indoly)propionicacid
3-Indolylpropionicacid
IPA, 3-Indole propionic acid
3-Indolepropionic acid, 99% 10GR
3-(1H-Indazol-1-yl)propanoic acid
3-Indole propionic acid (IPA)
Indole-3-propionic acid,3-(3-Indolyl)propanoic acid, 3-(3-Indolyl)propionic acid, IPA
3-Indolepropionic ac
beta-(3-Indolyl)propionic acid
beta-Indole-3-propionic acid
beta-Indolepropionic acid
3-(3-Indolyl)propanoic acid, Indole-3-propionic acid, IPA
3-(3-Indolyl)propanoic acid, 3-(3-Indolyl)propionic acid, IPA
2-Propanol : Water 31:69 with 0.1% buffer, 2-Propanol solution
N-Term LC Solvent System B
3-Indolepropionic acid ,99%
3-(3-IP)
NSC 3252
NSC 47831
2-Propanol : Water 31:69 with 0.1% buffer
3-Indolepropionic acid Vetec(TM) reagent grade, 99%