ChemicalBook >> CAS DataBase List >>Isoxepac
Isoxepac
- CAS No.
- 55453-87-7
- Chemical Name:
- Isoxepac
- Synonyms
- 2-(11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid;Olapatadine;6,11-DIHYDRO-11-OXO-DIBENZ[B,E]OXEPIN-2-ACETIC ACID;6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic Acid;artil;hp549;ND4-B2;isoxepac;P-720549;NSC 300907
- CBNumber:
- CB3466254
- Molecular Formula:
- C16H12O4
- Molecular Weight:
- 268.26
- MDL Number:
- MFCD00242952
- MOL File:
- 55453-87-7.mol
- MSDS File:
- SDS
Last updated:2024-10-19 16:57:28
| Melting point | 130-132°C |
|---|---|
| Boiling point | 528.2±50.0 °C(Predicted) |
| Density | 1.39 g/cm3 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| pka | 4.24±0.10(Predicted) |
| color | White to Light yellow to Light orange |
| Merck | 14,5237 |
| InChIKey | QFGMXJOBTNZHEL-UHFFFAOYSA-N |
| CAS DataBase Reference | 55453-87-7(CAS DataBase Reference) |
| FDA UNII |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301+H311-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P405 |
| Hazard Codes | T |
| Risk Statements | 25-62 |
| Safety Statements | 36/37-45 |
| RIDADR | UN 2811 6.1 / PGIII |
| RTECS | HQ4110000 |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 2932996560 |
| Toxicity | LD50 orally in rats: 199 mg/kg (Ueno) |
Isoxepac price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2539 | Olopatadine Related Compound C Pharmaceutical Secondary Standard; Certified Reference Material | 55453-87-7 | 50MG | $534 | 2025-03-01 | Buy |
| Sigma-Aldrich | 1478436 | Olopatadine Related Compound C United States Pharmacopeia (USP) Reference Standard | 55453-87-7 | 35mg | $1380 | 2025-03-01 | Buy |
| TCI Chemical | D4242 | 6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic Acid >97.0%(HPLC)(T) | 55453-87-7 | 1g | $60 | 2025-03-01 | Buy |
| TCI Chemical | D4242 | 6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic Acid >97.0%(HPLC)(T) | 55453-87-7 | 5g | $209 | 2025-03-01 | Buy |
| TRC | I917700 | Isoxepac | 55453-87-7 | 10g | $305 | 2022-12-16 | Buy |
Isoxepac Chemical Properties,Uses,Production
Chemical Properties
Beige SolidUses
Isoxepac is a non-steroidal anti-inflammatory with analgesic and antipyretic activity. It is more slowly absorbed and eliminated in the rat and rabbit after oral dosing than in the dog, rhesus monkey and man.It can be used to treat allergic rhinitis, urticaria, and skin diseases with itching symptoms.Preparation
Isoxic acid is an important intermediate in the synthesis of the new preferred anti-allergic drug, olopatadine hydrochloride, preparation method of isoxepac:
(1) condensation: prepare p-hydroxyphenylaceticacid 8-12 part, phthalide 6-12 part, sodium methylate 8-12 part by weight; Dissolve with DMAC and to add said sodium methylate behind said p-hydroxyphenylaceticacid and the phthalide; Be that 0.1-10Pa is heated to 80-170 ℃ of reaction 3-10h at pressure then; Regulate the pH value to 1-5,4-(2-carboxyl benzyloxy) toluylic acid is separated out in crystallization;
(2) cyclization: with Glacial acetic acid min. 99.5 dissolving step (1) gained 4-(2-carboxyl benzyloxy) toluylic acid, adding 3-52 weight part polyphosphoric acid again, is that 0.1-10Pa is heated to 30-100 ℃ of reaction 3-12h at pressure, and crystallisation by cooling gets the Isoxepac bullion then;
(3) purify: behind the said Isoxepac bullion of acetic acid ethyl dissolution, refining decolouring gets the Isoxepac product.
//patents.google.com/patent/CN102838582A/en
Definition
ChEBI: Isoxepac is a dibenzooxazepine.brand name
Artil(Hoechst-Roussel) .
Isoxepac Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 356)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
| Changzhou Rokechem Technology Co., Ltd. | 18758118018 | sales001@rokechem.com | China | 255 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12452 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5964 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9353 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
View Lastest Price from Isoxepac manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-19 | Isoxepac
55453-87-7
|
US $40.00-40.00 / kg | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2024-09-26 | Isoxepac
55453-87-7
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2024-09-06 | Isoxepac
55453-87-7
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. |
6,11-dihydro-11-oxo-dibenz[b,e]oxepin-2-acetic acid (Olopatadine)
Olopatadine Related Compound C (35 mg) ((11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid)
ND4-B2
artil
isoxepac
(11-OXO-6,11-DIHYDRODIBENZO[B,E]OXEPIN-2-YL)ACETIC ACID
11-Oxo-6,11-dihydrodibenz[b,e]oxepin-2-acetic Acid
NSC 300907
Isoxepac-d6
Olopatadine Related CoMpund C
Olopatadine Related CoMpound C
Olopatadine USP RC C
e)oxepin-2-aceticacid,6,11-dihydro-11-oxo-dibenz(
hp549
DIBENZ[B,E]OXEPIN-2-ACETIC ACID, 6,11-DIOHYDRO-11-OXO
6,11-Hydro-11-Oxo-Dibenz[B,E]Oxepin-2-Acetic Acid
11-Oxo-6,11-Dihydrobenz(b,e)oxepin-2-Acetic Acid (Isoxepac)
Isoxepac (Dibenz[b,e]oxepin-2-acetic acid, 6,11-dihydro-11-oxo)
6,11-Dihydro-11-oxo-dibenz[b,e]oxepin-2-acetic
6,11-Dihydro-11-oxodibenz[b,e]oxepine-2-acetic acid
P-720549
6,11-dihydro-11-oxodibenz[b,e]opepin-2-acetic acid
2-(11-keto-6H-benzo[c][2]benzoxepin-2-yl)acetic acid
2-(11-oxo-6H-benzo[c][2]benzoxepin-2-yl)acetic acid
2-(11-oxo-6H-benzo[c][2]benzoxepin-2-yl)ethanoic acid
6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid (Isoxepac)
6,11-DIHYDRO-11-OXO-DIBENZ[B,E]OXEPIN-2-ACETIC ACID(FOR OLOPATADINE)
Olotatadine related compound C
Olopatadine USP Related Compound C
e]oxepin-2-acetic acid
11-Dihydro-11-oxo-dibenz[b
6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-aceticAcid>
Dibenz[b,e]oxepin-2-acetic acid, 6,11-dihydro-11-oxo-
Olopatadine Related Compound C (35 mg)
6H-11-Oxodibenzo[b,e]oxepin-2-acetic Acid
TIANFU-CHEM 55453-87-7 Isoxepac
Olopatadine Related Compound C ((11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid) (1478436)
16-trihydroxy-palmitic acid
Olopatadine Impurity 3（Olopatadine USP RC C）
6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic acid, 97.0%
Isoxepac-HBW
6,11-DIHYDRO-11-OXO-DIBENZ[B,E]OXEPIN-2-ACETIC ACID
6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic Acid
Olapatadine
2-(11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid
Olotadine Hydrochloride Isoclate
(11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic Acid (Isoxepac)
Isoxic acid
2-(11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)aceticaci
55453-87-7
1313-91-1
55453-67-7
C16H12O4
API
Pharmaceutical intermediate
APIs Intermediate
Intermediates & Fine Chemicals
Pharmaceuticals