ChemicalBook >> CAS DataBase List >>2-Piperidone
2-Piperidone
- CAS No.
- 675-20-7
- Chemical Name:
- 2-Piperidone
- Synonyms
- piperidin-2-one;2-PIPERIDINONE;VALEROLACTAM;DELTA-VALEROLACTAM;5-Aminovaleric acid lactam;valerolactim;D-VALEROLACTAM;ALPHA-PIPERIDONE;Piperidon;Piperidone-2
- CBNumber:
- CB3680771
- Molecular Formula:
- C5H9NO
- Molecular Weight:
- 99.13
- MDL Number:
- MFCD00006037
- MOL File:
- 675-20-7.mol
- MSDS File:
- SDS
Last updated:2025-04-07 18:44:46
| Melting point | 38-40 °C (lit.) |
|---|---|
| Boiling point | 256 °C (lit.) 81-82 °C/0.1 mmHg (lit.) |
| Density | 1.073 |
| refractive index | 1.4431 (estimate) |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Low Melting Crystalline Mass |
| color | White to yellow to brown |
| PH | 4.8 (200g/l, H2O, 20℃) |
| explosive limit | 1.5-8.7%(V) |
| Water Solubility | 291 g/L (25 ºC) |
| Sensitive | Hygroscopic |
| BRN | 106434 |
| Stability | Stable under recommended storage conditions., Stable Under Recommended Storage C |
| InChIKey | XUWHAWMETYGRKB-UHFFFAOYSA-N |
| CAS DataBase Reference | 675-20-7(CAS DataBase Reference) |
| EWG's Food Scores | |
| FDA UNII | |
| NIST Chemistry Reference | |
| EPA Substance Registry System |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37-36/37/38 | |||||||||
| Safety Statements | 22-24/25-37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TO0110000 | |||||||||
| F | 3-10 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29337900 | |||||||||
| NFPA 704 |
|
2-Piperidone price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | V209 | δ-Valerolactam 98% | 675-20-7 | 25g | $80.7 | 2025-03-01 | Buy |
| Sigma-Aldrich | V209 | δ-Valerolactam 98% | 675-20-7 | 100g | $212 | 2025-03-01 | Buy |
| TCI Chemical | P0455 | 2-Piperidone >98.0%(GC) | 675-20-7 | 25g | $68 | 2025-03-01 | Buy |
| TCI Chemical | P0455 | 2-Piperidone >98.0%(GC) | 675-20-7 | 100g | $184 | 2025-03-01 | Buy |
| Alfa Aesar | A12271 | delta-Valerolactam, 98% | 675-20-7 | 25g | $60.65 | 2025-03-01 | Buy |
2-Piperidone Chemical Properties,Uses,Production
Chemical Properties
white to yellowish low melting crystalline massUses
δ-Valerolactam is a useful synthetic intermediate. It is an intermediate used to synthesize Cenicriviroc (C256550), an experimental drug candidate for the treatment of HIV infection. It is also a starting material for a new route to hexahydrojulolidines, using intramolecular 1,4-cycloaddition.Definition
ChEBI: 2-Piperidone is a delta-lactam that is piperidine which is substituted by an oxo group at position 2. It has a role as an EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor. It is a member of piperidones and a delta-lactam.Preparation
2-Piperidone can be obtained from cyclopentanone as raw material by a two-step reaction.Synthesis Reference(s)
Journal of the American Chemical Society, 102, p. 7629, 1980 DOI:
Tetrahedron Letters, 28, p. 2829, 1987 DOI:
The Journal of Organic Chemistry, 21, p. 965, 1956 DOI:
Purification Methods
Purify it by repeated fractional distillation.[Cowley J Org Chem 23 1330 1958, Reppe et al. Justus Liebigs Ann Chem 596 198 1955, IR: Huisgen et al. Chem Ber 90 1437 1957.] The hydrochloride has m 183-184o (from isoPrOH or EtOH/Et2O) [Hurd et al. J Org Chem 17 865 1952], and the oxime has m 122.5o (from pet ether) [Behringer & Meier Justus Liebigs Ann Chem 607 67 1957]. The picrate has m 92-93o. [Beilstein 21 H 239, 21 III/IV 3170, 21/6 V 396.]2-Piperidone Preparation Products And Raw materials
Global( 389)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 6000 | 58 |
| Shandong Huisheng Import & Export Co., Ltd. | +86-13176845580 +86-13176845580 | da@zhongda-biotech.com | China | 248 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 300 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8615689548120 | linda@zhongda-biotech.com | China | 204 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Shandong Juchuang Chemical Co., LTD | +undefined15030412209 | admin@juchuangchem.com | China | 387 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 811 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1011 | 58 |
View Lastest Price from 2-Piperidone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-10 | 2-Piperidone
675-20-7
|
US $23.00-3.00 / kg | 1kg | 99% | 300tons | Hebei Dangtong Import and export Co LTD | |
 |
2025-04-07 | 2-Piperidone
675-20-7
|
US $23.00-18.00 / kg | 1kg | 99% | 5000tons | Wuhan Boyuan Import & Export Co., LTD | |
 |
2025-03-11 | 2-Piperidone
675-20-7
|
US $65.00-45.00 / kg | 500kg | 99.9 | 200tons | Shandong Juchuang Chemical Co., LTD |
-
- 2-Piperidone
675-20-7
- US $23.00-3.00 / kg
- 99%
- Hebei Dangtong Import and export Co LTD
-
- 2-Piperidone
675-20-7
- US $23.00-18.00 / kg
- 99%
- Wuhan Boyuan Import & Export Co., LTD
-
- 2-Piperidone
675-20-7
- US $65.00-45.00 / kg
- 99.9
- Shandong Juchuang Chemical Co., LTD
675-20-7(2-Piperidone)Related Search:
2-Piperidinone for synthesis
2-KETOPIPERIDINE
2-AZACYCLOHEXANONE
5-pentanelactam
5-Pentanolactam
Pentanoic acid, 5-amino-, lactam
Piperidon
Piperidone-2
delta-Valerolactame
delta-Valerolactam,97%
i-valerolactam
3,4,5,6-Tetrahydropyridine-2-ol
^d-Valerolactam, 98+%
delta-Valerolactam,99%
δ-Valerolactam, 98+%
6-VALEROLACTAM
2-PIPERIDONE
2-Piperidone ,98.5%
2-Oxo-piperidine
delta-Valerolactam, 2-Azacyclohexan-1-one
Piperidin-5-one
Piperidin-6-one
Piperidin-7-one
delta-ValerolactaM, 99% 100GR
delta-ValerolactaM, 99% 25GR
delta-ValerolactaM, 99% 5GR
2-Azacyclohexanone
delta-Valerolactam
2-Piperidone Synonyms Piperidin-2-one
δ-Valerolactam, >=99%
delta-Valerolactam, 98+%
delta-ValerolactaM 98%
2-Piperidone, 97+%
Left Bupivacaine Impurity 10
3-CHLORO-2-(HYDROX...
2-Piperidone>
Bupivacaine Impurity 26
2-PIPERIDONE 675-20-7
valerolactim
5-Aminovaleric acid lactam
VALEROLACTAM
piperidin-2-one
D-VALEROLACTAM
DELTA-VALEROLACTAM
ALPHA-PIPERIDONE
2-PIPERIDINONE
RSSYY(Perospirone Hydrochloride Hydrate)-14
RSSYY(Perospirone Hydrochloride Hydrate)-11
2-Piperidone (8CI)
Piperidone impurity 2（Bupivacaine Impurity7）
Valarolactam
Meso-2,4-Dichloropentane
675-20-7
675-20-8
675-20-9
Lactams
Organic Building Blocks
Building Blocks
Carbonyl Compounds