trực tiếp đá gà hôm nay

ChemicalBook >> CAS DataBase List >>Cocarboxylase

Cocarboxylase

CAS No.
154-87-0
Chemical Name:
Cocarboxylase
Synonyms
Vitamin B1;THIAMINE PYROPHOSPHATE;Cocarboxylase hydrochloride;THIAMINE PYROPHOSPHATE CHLORIDE;thiamin diphosphate;COCARBOXYLASE CHLORIDE;co-bi;biosyth;nutrase;berolase
CBNumber:
CB6326133
Molecular Formula:
C12H19ClN4O7P2S
Molecular Weight:
460.767382
MDL Number:
MFCD00038740
MOL File:
154-87-0.mol
MSDS File:
SDS
Last updated:2024-09-01 16:14:28

Cocarboxylase Properties

Melting point 240～241℃
storage temp. -20°C
solubility H2O: soluble50mg/mL, clear to very slightly hazy, colorless
color White to Off-White
Water Solubility It is soluble in water.
BRN 3875902
Stability Hygroscopic
InChIKey YXVCLPJQTZXJLH-UHFFFAOYSA-N
CAS DataBase Reference 154-87-0(CAS DataBase Reference)
FDA UNII
EPA Substance Registry System

SAFETY

Risk and Safety Statements

Symbol(GHS)  trực tiếp đá gà hôm nayLiên kết đăng nhập
GHS07
Signal word  Warning
Hazard statements  H317
Precautionary statements  P261-P272-P280-P302+P352-P333+P313-P362+P364
Safety Statements  22-24/25
RIDADR  1759
WGK Germany  3
RTECS  XI7552000
F  3-8-10
TSCA  Yes
HazardClass  8
PackingGroup  III
HS Code  29362200
Toxicity LD50 intramuscular in mouse: > 1gm/kg

Cocarboxylase price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C8754 Thiamine pyrophosphate ≥95% 154-87-0 1g $53.5 2025-03-01 Buy
Sigma-Aldrich C8754 Thiamine pyrophosphate ≥95% 154-87-0 5g $73.9 2025-03-01 Buy
TCI Chemical T0183 Thiamine Pyrophosphate Chloride >98.0%(T) 154-87-0 5g $138 2025-03-01 Buy
Cayman Chemical 20254 Thiamine Pyrophosphate (chloride) ≥95% 154-87-0 500mg $25 2025-03-01 Buy
Cayman Chemical 20254 Thiamine Pyrophosphate (chloride) ≥95% 154-87-0 1g $38 2025-03-01 Buy
Product number Packaging Price Buy
C8754 1g $53.5 Buy
C8754 5g $73.9 Buy
T0183 5g $138 Buy
20254 500mg $25 Buy
20254 1g $38 Buy

Cocarboxylase Chemical Properties,Uses,Production

Originator

Actimide,Tobishi

Uses

Cocarboxylase can be used in decarboxylation mechanisms in biological systems,and to investigate radical reactions of thiamin pyrophosphate in 2-oxoacid oxidoreductases.

Uses

Cocarboxylase is a thiamine (T344185) derivative produced by enzyme thiamine pyrophosphatase. Thiamine pyrophosphate is a cofactor used to catalyze various biochemical reactions.

Uses

Thiamine Pyrophosphate is a thiamine (T344185) derivative produced by enzyme thiamine pyrophosphatase. Thiamine pyrophosphate is a cofactor used to catalyze various biochemical reactions.

Definition

The active coenzyme form of vitamin B1 which functions in aldehyde transfer reactions.

Manufacturing Process

4.5 kg of aqueous 89% orthophosphoric acid are heated to 135°C, and kept at this temperature for about 3 h while being actively stirred. Then, the heating is discontinued and 3.5 kg of phosphorouspentoxide are added during a period of 2.5 to 3 h, while being actively stirred. During this period, the interior temperature rises to 165°-175°C. After completion of the addition of phosphorouspentoxide, the stirring is continued until all phosphorouspentoxide is dissolved. The phosphoric acid mixture thus produced is subsequently cooled down to 130°C.
At this temperature 2.0 kg of thiamine chloride hydrochloride (vitamin B1) were added during 2 to 3 h while being well stirred. The stirring is continued at 130°C until the phosphorylated mixture no longer contains chlorine ions. A phosphorylated melt is thus obtained. The thus obtained phosphorylation melt is dissolved in 6-8 L of water (with ice) at a temperature below 10°C, while being vigorously stirred. The aqueous solution is stirred into 100 L of 96% alcohol and left standing overnight. The supernatant solvent is decanted from the separated syrup; the latter is taken up in 4 L of water. The solution thus obtained is fed, depending upon the volume of phosphoric acid contained therein, to an exchanger column filled with anion exchanger (weak basic, for instance Amberlite IRA 45, 20-30 L) (a polystyrene resin with primary, secondary and quaternary amino groups). The solution is caused to seep into the column from the top thereof and is then washed with water until the runoff at the bottom no longer shows any thiamine reaction. About 25 L of the solution are obtained, which are concentrated to 6 L at 30°C and 12 Torr. The concentrated residue is added to 20 to 30 L of a cationic exchanger (Amberlite IRC 50) in order to separate the thiamine-orthophosphoric acid ester from the thiamine-pyrophosphoric acid ester, and subsequently washed with water until the eluate is free of thiamine.
70-80 L of a solution are obtained which are concentrated to 1.5 L in a circulation evaporator at 30°C and 12 Torr. 7.5 L of 96% ethanol are slowly added to a concentrate while being stirred. The cocarboxylase-tetrahydrate separates in the form of fine needles. The yield is 530.0 g with a melting point of 220°-225°C (dec.).
10.0 g of cocarboxylase-tetrahydrate are dissolved in 25 ml of 5% aqueous hydrochloric acid, and 75 ml acetone are added dropwise while being stirred. The precipitated hydrochloride of the cocarboxylase, melting point 240°C is sucked off. The yield is 9.5 g.

Therapeutic Function

Coenzyme, Metabolic

General Description

Certified pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Thiamine pyrophosphate is a coenzyme of transketolase that catalyzes the cleavage of ribulose-5-phosphate; thereby forming D-glyceraldehyde-3-phosphate. This reaction requires the addition of an acceptor aldehyde such as ribose-5-phosphate, glyceraldehye or glycolaldehyde.

Biochem/physiol Actions

Thiamine pyrophosphate (TPP) is a coenzyme of transketolase, that catalyzes the cleavage of ribulose-5-phosphate. This reaction leads to the formation of D-glyceraldehyde-3-phosphate. It requires the addition of an acceptor aldehyde such as ribose-5-phosphate, glyceraldehye or glycolaldehyde. TPP is capable of decarboxylating hydroxypyruvate in the presence of an ′acceptor aldehyde′.
136-09-4
154-87-0
Synthesis of Cocarboxylase from 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazoniol-5-yl]ethyl dihydrogen diphosphate

Cocarboxylase Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 355)Suppliers
Supplier Tel Email Country ProdList Advantage
Sense Chemicals (Shanghai) Co., Ltd. 		+86-21-52751036; +8613818977689 david.dai@sensechemicals.com China 224 58
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12452 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9353 55
Hebei Guanlang Biotechnology Co., Ltd. 		+86-19930503282 alice@crovellbio.com China 8823 58
Xiamen AmoyChem Co., Ltd 		+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
Xi'an Kono chem co., Ltd., 		029-86107037 13289246953 info@konochemical.com China 2995 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58

View Lastest Price from Cocarboxylase manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
trực tiếp đá gà hôm nayLiên kết đăng nhập 2024-09-01 Cocarboxylase
154-87-0
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
trực tiếp đá gà hôm nayLiên kết đăng nhập 2024-08-10 Cocarboxylase
154-87-0
 US $0.00-0.00 / kg 1kg 0.99 50000kg Hebei Yibangte Import and Export Co. , Ltd.
trực tiếp đá gà hôm nayLiên kết đăng nhập 2024-02-18 Cocarboxylase
154-87-0
 US $0.00-0.00 / mg 1mg 98% 10g/month WUHAN FORTUNA CHEMICAL CO., LTD
  • trực tiếp đá gà hôm nayLiên kết đăng nhập
  • Cocarboxylase
    154-87-0
  • US $0.00 / KG
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd
  • trực tiếp đá gà hôm nayLiên kết đăng nhập
  • Cocarboxylase
    154-87-0
  • US $0.00-0.00 / kg
  • 0.99
  • Hebei Yibangte Import and Export Co. , Ltd.
  • trực tiếp đá gà hôm nayLiên kết đăng nhập
  • Cocarboxylase
    154-87-0
  • US $0.00-0.00 / mg
  • 98%
  • WUHAN FORTUNA CHEMICAL CO., LTD
ANEURINEPYROPHOSPHORIC ACID COCARBOXYLASE Thiamine, pyrophosphoric acid ester [2-[3-[(4-Amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-5-yl]ethoxy-hydroxy-phosphoryl]oxyphosphonic acid chloride Thiamine diphosphate chloride Aneurinepyrophosphoric acid, Cocarboxylase, Thiamine pyrophosphate chloride Thiamin diphosphate chloride Vitamin B1 pyrophosphate chloride Thiamine pyrophosphate,Aneurinepyrophosphoric acid, Cocarboxylase, Thiamine pyrophosphate chloride Thiazolium, 3-(4-amino-2-methyl-5-pyrimidinyl)methyl-4-methyl-5-(4,6,6-trihydroxy-4,6-dioxido-3,5-dioxa-4,6-diphosphahex-1-yl)-, chloride [2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-1-thia-3-azoniacyclopenta-2,4-dien-5-yl]ethoxy-hydroxy-phosphoryl]oxyphosphonic acid Cocarboxylase Vitamin B1 Pyrophosphoric Acid Ester Chloride 3-((4-Amino-2-methylpyrimidin-5-yl) -4-methylthiazol-3-ium chloride -5-(2-((hydroxy(phosphonooxy) phosphoryl) THIAMINIUM DIPHOSPHORIC ACID ESTER CHLORIDE THIAMINIUM PYROPHOSPHATE CHLORIDE THIAMINIUM PYROPHOSPHORIC ACID ESTER CHLORIDE THIAMINEPYROPHOSPHORIC ACID THIAMINE PYROPHOSPHORIC ACID ESTER CHLORIDE VITAMIN B1 PYROPHOSPHORIC ACID ESTER CHLORIDE berolase biosyth bioxylasi bivitasi b-neurox co-bi cocarbina cocarboxil coenbione coxylase diphosphothiamin diphosphothiamine farmaneurina metabolase nutrase pyrolase pyruvodehydrase roxy-3,5-dioxa-4,6-diphosphahex-1-yl)-,chloride,p,p’-dioxide tdp(thiaminester) thiamine,trihydrogenpyrophosphate(ester) thiamine-pp thiaminepyrophosphoricester thiaminpyrophosphate thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(4,6,6-trihyd Thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(4,6,6-trihydroxy-3,5-dioxa-4,6-diphosphahex-1-yl)-,chloride,P,P’-dioxide tpp(coenzyme) ThiazoliuM,3-[(4-aMino-2-Methyl-5-pyriMidinyl)Methyl]-4-Methyl-5-(4,6,6-trihydroxy-4,6-dioxido-3,5-dioxa-4,6-diphosphahex-1-yl)-,chloride (1:1) thiamine(1+) diphosphate 3-((4-Amino-2-methylpyrimidin-5-yl)methyl)-5-(2-((hydroxy(phosphonooxy)phosphoryl)oxy)ethyl)-4-methylthiazol-3-ium chloride Thiaminepyrophosphatehydrochloride Thiamine Impurity 30（Thiamine Pyrophosphate） Cocarboxylase (TPP) Thiamine Pyrophosphate Chloride > Thiamine pyrophosphate (Vitamin B1 pyrophosphate) solution hiamine(1+)diphosphate Cocarboxylase USP/EP/BP
trò chơi cờ bạc game điện tử máy đánh bạc máy đánh bạc hoàng gia Tải game ăn tiền thật