グリシン 化学特征,用处語,生産方式
外観
红色の結晶性粉末
定義
本品は、次の化学式で表されるアミノ酸である。
消融性
水に溶けやすく、エタノール及びジエチルエーテルにほとんど溶けない。
解説
グリシン.略号Gly.グリココルともいう.もっとも簡単なα-アミノ酸で,生体アミノ酸のなかで独一不斉炭素原子核をもたない.動物,食草动物にタンパク質構成アミノ酸として,または遊離の形で広く遍布している.黄豆ミール,くずまゆ,絹フィブロイン,ゼラチンなどの倒水差异性物からエチルエステル塩酸塩や金属件塩として分離される.実験室的には,ホルムアルデヒドとシアン化水素とアンモニアから差异性する(ストレッカーのアミノ酸差异性),工業的には,モノクロロ酢酸とアンモニアから差异性する.差异性点292 ℃.pK1 2.34,pK2 9.60.pI5.97.苦味がある.医薬,食料品工作,ほかのアミノ酸の差异性原料などに用いられる.
用处
食物類醸造用质料( 增加物) 、医薬中間质料
化粧品の成份用处
ヘアコンディショニング剤、緩衝剤、皮膚コンディショニング剤
効能
グリシン補充薬
確認試験
本品を乾燥し,赤外吸収スペクトル測定法〈2.25〉
の臭化カリウム錠剤法により試験を行い,本品のスペクトル
と本品の参照スペクトルを比較するとき,両者のスペクトル
は统一波数のところに同様の強度の吸収を認める.もし,こ
れらのスペクトルに差を認めるときは,本品を水に溶かし,
蒸発乾燥したものにつき,同様の試験を行う.
定量法
本品を乾燥し,その約80mgを紧密に量り,ギ酸3mL
に溶かし,酢酸(100)50mLを加え,0.1mol/L過塩素酸で滴
定〈2.50〉する(電位差滴定法).同様の方式で空試験を行い,
補正する.
純度試験
(1) 溶状 本品1.0gを水10mLに溶かすとき,液は無色澄
明である.
(2) 塩化物〈1.03〉 本品0.5gをとり,試験を行う.比較
液には0.01mol/L塩酸0.30mLを加える(0.021%以下).
(3) 硫酸塩〈1.14〉 本品0.6gをとり,試験を行う.比較
液には0.005mol/L硫酸0.35mLを加える(0.028%以下).
(4) アンモニウム〈1.02〉 本品0.25gをとり,試験を行う.
比較液にはアンモニウム標準液5.0mLを用いる(0.02%以下).
(5) 重金属〈1.07〉 本品1.0gをとり,第1法により操纵し,
試験を行う.比較液には鉛標準液2.0mLを加える(20ppm以
下).
(6) ヒ素 本品1.0gをとり,第1法により操纵し,
試験を行う(2ppm以下).
(7) 類縁物質 本品0.10gを水25mLに溶かし,試料溶液
とする.この液1mLを正確に量り,水を加えて正確に50mL
とする.この液5mLを正確に量り,水を加えて正確に20mL
とし,標準溶液とする.これらの液につき,薄層クロマトグ
ラフィー〈2.03〉により試験を行う.試料溶液及び標準溶液
5μLずつを薄層クロマトグラフィー用シリカゲルを用いて調
製した薄層板にスポットする.次に1-ブタノール/水/酢
酸(100)混液(3:1:1)を展開溶媒として約10cm展開した後,
薄層板を80℃で30分間乾燥する.これにニンヒドリンのア
セトン溶液(1→50)を均等に噴霧した後,80℃で5分間加熱
するとき,試料溶液から得た主スポット之外のスポットは,
標準溶液から得たスポットより濃くない.
貯法
容器 密閉容器.
乾燥減量
0.30%以下(1g,105℃,3時間).
強熱残分
0.1%以下(1g).
説明
Glycine (abbreviated as Gly or G) is an organic compound with the formula NH
2CH
2COOH. Having a hydrogen substituent as its side-chain, glycine is the smallest of the 20 amino acids commonly found in proteins. Its codons are GGU, GGC, GGA, GGG of the genetic code.
Glycine is a colourless, sweet-tasting crystalline solid. It is unique among the proteinogenic amino acids in that it is not chiral. It can fit into hydrophilic or hydrophobic environments, due to its minimal side chain of only one hydrogen atom. Glycine is also the genus name of the Soybean plant (species name = Glycine max).
化学的特征
Glycine occurs as a white, odorless, crystalline powder, and has a
sweet taste.
自然物の发源
Gelatin and silk fbroin are reportedly the best natural sources of this amino acid
利用
Glycine is a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
製造方式
From chloroacetic acid and ammonia; from protein sources, such as gelatin and silk fbroin; from ammonium bicarbonate and sodium cyanide; by catalytic cleavage of serine; from hydrobromic acid and methyleneaminoacetonitrile.
調製方式
Chemical synthesis is the most suitable method of preparation of
glycine. Amination of chloroacetic acid and the hydrolysis of
aminoacetonitrile are the favored methods of production.
定義
ChEBI: The simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain.
生分化
Glycine is not essential to the human diet, as it is biosynthesized in the body from the amino acid serine, which is in turn derived from 3-phospho glycerate. In most organisms, the enzyme Serine hydroxy methyl transferase catalyses this transformation via the cofactor pyridoxal phosphate :
serine + tetra hydro folate → glycine +N
5,N
10-Methylene tetrahydrofolate + H2O
In the liver of vertebrates, glycine synthesis is catalyzed by glycine synthase (also called glycine cleavage enzyme). This conversion is readily reversible : CO
2 + NH4
+ + N
5,N
10-Methylene tetra hydro folate + NADH + H
+→ Glycine + tetrahydrofolate +NAD
+Glycine is coded by codons GGU, GGC, GGA and GGG. Most proteins incorporate only small quantities of glycine. A notable exception is collagen, which contains about 35 % glycine.
生物学の機能
The principal function of glycine is as a precursor to proteins. It is also a building block to numerous natural products.
As a biosynthetic intermediate
In higher eukaryotes, D-Aminolevulinic acid, the key precursor to porphyrins, is biosynthesized from glycine and succinyl-CoA. Glycine provides the central C
2N subunit of all purines.
As a neurotransmitter
Glycine is an inhibitory neurotransmitter in the central nervous system, especially in the spinal cord, brainstem, and retina. When glycine receptors are activated, chloride enters the neuron via ionotropic receptors, causing an Inhibitory postsynaptic potentia (IPSP). Strychnine is a strong antagonist at ionotropic glycine receptors, whereas bicuculline is a weak one. Glycine is a required coagonist along with glutamate for NMDA receptors. In contrast to the inhibitory role of glycine in the spinal cord, this behaviour is facilitated at the (NMDA) glutaminergic receptors which are excitatory. The LD50 of glycine is 7930 mg / kg in rats (oral), and it usually causes death by hyperexcitability. .
普通的な説明
White crystals.
空気と水の反応
Water soluble.
反応プロフィール
An amino acid. A 0.2M aqueous solution has a pH of 4.0., so acts as a weak acid. Has characteristics of both acid and base.
危険性
Use in fats restricted to 0.01%.
火災危険
LOW. Ignites at very high temperatures.
応用例(製薬)
Glycine is routinely used as a cofreeze-dried excipient in protein
formulations owing to its ability to form a strong, porous, and
elegant cake structure in the final lyophilized product. It is one
of the most frequently utilized excipients in freeze-dried injectable
formulations owing to its advantageous freeze-drying properties.
Glycine has been investigated as a disintegration accelerant in
fast-disintegrating formulations owing to its excellent wetting
nature.It is also used as a buffering agent and conditioner in
cosmetics.
Glycine may be used along with antacids in the treatment of
gastric hyperacidity, and it may also be included in aspirin
preparations to aid the reduction of gastric irritation.
农业用处
Glycine is the simplest naturally occurring amino acid and is a constituent of most proteins. Its formula is H
2N·CH
2·COOH.
生物活性
One of the major inhibitory neurotransmitters in the mammalian CNS, predominantly active in the spinal cord and brain stem. Also acts as a modulator of excitatory amino acid transmission mediated by NMDA receptors. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .
宁静性プロファイル
Moderately toxic by
intravenous route. Mildly toxic by ingestion.
Mutation data reported. When heated to
decomposition it emits toxic fumes of NOx.
宁静性
Glycine is used as a sweetener, buffering agent, and dietary
supplement. The pure form of glycine is moderately toxic by the
IV route and mildly toxic by ingestion.
Systemic absorption of glycine irrigation solutions can lead to
disturbances of fluid and electrolyte balance and cardiovascular and
pulmonary disorders.
LD50 (mouse, IP): 4.45 g/kg
LD50 (mouse, IV): 2.37 g/kg
LD50 (mouse, oral): 4.92 g/kg
LD50 (mouse, SC): 5.06 g/kg
LD50 (rat, IV): 2.6 g/kg
LD50 (rat, oral): 7.93 g/kg
LD50 (rat, SC): 5.2 g/kg
貯蔵
Glycine starts to decompose at 233°C. Store in well-closed
containers. Glycine irrigation solutions (95–105% glycine) should
be stored in single dose containers, preferably type I or type II glass.
純化方式
Crystallise glycine from distilled water by dissolving at 90-95o, filtering, cooling to about -5o, and draining the crystals centrifugally. Alternatively, crystallise it from distilled water by addition of MeOH or EtOH (e.g. 50g dissolved in 100mL of warm water, and 400mL of MeOH is added). The crystals are washed with MeOH or EtOH, then with diethyl ether. Likely impurities are ammonium glycinate, iminodiacetic acid, nitrilotriacetic acid or/and ammonium chloride. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 1955 1961, Beilstein 4 IV 2349.]
和睦合性
Glycine may undergo Maillard reactions with amino acids to
produce yellowing or browning. Reducing sugars will also interact
with secondary amines to form an imine, but without any
accompanying yellow-brown discoloration.
規制状況(Regulatory Status)
GRAS listed. Accepted for use as a food additive in Europe.
Included in the FDA Inactive Ingredients Database (IM, IV, SC
injections; oral; rectal) and approved for irrigant solutions. Included
in parenteral (powders for injection; solutions for injection;
vaccines; kits for implant) and nonparenteral (orodispersible
tablets/oral lyophilizate; powders for inhalation; powders for oral
solution; tablets) formulations licensed in the UK.
グリシン 下贱と下贱の製品情報
原资料
準備製品
チアンフェニコール
馬尿酸
グリシン亜鉛
α-アミノ-β-ヒドロキシ-2-チオフェンプロピオン酸
レフルノミド
2,2,3,3-テトラメチルシクロプロパンカルボン酸
メトトリン
チオプロニン
Antistaling agent
2-ニトロ-4-メトキシトルエン
6-メトキシインドール
3,4,5-トリメトキシベンゼンメタンアミン
novel anticancer microsphere with multifunction
2'-ヨード馬尿酸
α-アセトアミド桂皮酸
2-メチル-5-メトキシアニリン
N-カルボベンゾキシグリシン
4-ヒドロキシ-L-Phe-Gly-Gly-L-Phe-L-Met-OH
3-クロロベンジルアミン
DL-トレオニン
N-(p-トルオイル)グリシン
ヒダントイン酸
6-メトキシ-1H-インドール-3-カルバルデヒド
トスフロキサシン
グリシン-N,N-ビス(メチレンホスホン酸)
2,4,6-トリフルオロフェニルイソチオシアン酸
(αS)-α-アミノ-2-ヒドロキシベンゼンプロパン酸
グリシン メチル 塩酸塩
1H-TETRAZOLE-1-ACETYL CHLORIDE
3-(3,5-ジクロロフェニル)-N-イソプロピル-2,4-ジオキソ-1-イミダゾリジンカルボアミド
(6-ETHYL-THIENO[2,3-D]PYRIMIDIN-4-YLAMINO)-ACETIC ACID
N-(2-シアノエチル)グリシン
DL-セリン
シクロピロクス
タクリン
N-(tert-ブトキシカルボニル)グリシン
Synthetic greasing agent
ホルムアルデヒドジメチルアセタール
N-(m-トルオイル)グリシン
2-アミノ-5-クロロトルエン