Antimicrobial, cytotoxic, and antioxidant activities and physicochemical characteristics of chromium(III) complexes with
Dec 1,2023
The studies on chromium(III) complexes were performed using both chemical and biological methods. PT and CT analyses allowed for the examination of properties of the complexes [Cr(dipic)2]Hdmbipy∙2.5H2O, [Cr(2-pic)2(H2O)2]NO3, [Cr(dipic)2][Cr(bipy)(dipic)H2O]∙2H2O, cis-K [Cr(C2O4)2(H2O)2], and trans-K[Cr(C2O4)2(H2O)2]·3H2O. The reactivity of the tested complexes toward a superoxide anion radical was investigated using the NBT test. EA values reveal the highest antioxidant activity for [Cr(dipic)2][Cr(bipy)(dipic)H2O]∙2H2O, which is a stronger antioxidant than the known antioxidant L-ascorbic acid. Biological study results show that the complexes 1 and 3 exert bacteriostatic activities against some of the bacterial species (B. subtilis and E. coli). The analysis of the results of the potential cytotoxicity of these agents reveal that the complexes 2–5 show no cytotoxic activities against human keratinocytes at concentrations up to 200–500 μM in 24 h. The exception is compound 1 that shows maximum cytotoxicity and strongly affects cell viability in a time and dose-dependent manner.
The results presented in this report may be useful for further studies evaluating the effects of the tested chromium(III) complexes on human body as antioxidants or dietary supplements substituting Cr(pic)3.References:[1] JOANNA DRZEŻDŻON . Antimicrobial, cytotoxic, and antioxidant activities and physicochemical characteristics of chromium(III) complexes with picolinate, dipicolinate, oxalate, 2,2′-bipyridine, and 4,4′-dimethoxy-2,2′-bipyridine as ligands in aqueous solutions[J]. Journal of Molecular Liquids, 2019, 282: Pages 441-447. DOI:10.1016/j.molliq.2019.03.049.- Related articles
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