Sofosbuvir synthesis
- Product Name:Sofosbuvir
- CAS Number:1190307-88-0
- Molecular formula:C22H29FN3O9P
- Molecular Weight:529.45
863329-66-2
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1190307-88-0
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1-8 Example 1
Add 20.0 g (0.0768 mol) of Compound 1 to the reaction flask, add 40.0 g (0.0882 mol) of Compound 2 and 150 g of dichloromethane, cool to 0 ° C, add aluminum trichloride 3.1 g (0.0232 mol), and add pyridine dropwise 24.3g (0.307mol); then the reaction was performed at 20 ° C, and the reaction was stopped when the content of sofosbuvir was no longer increased by HPLC. At this time, the HPLC data related to compound 1 in the reaction solution:To the reaction solution, 120 g of 10% dilute hydrochloric acid was added to quench the reaction, 300 g of ethyl acetate was extracted, the solvent was recovered under reduced pressure, and 39.68 g of pure Sofibuvir was obtained by purification, with a yield of 97.5%.
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1256490-31-9
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1190307-88-0
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1256490-52-4
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1190307-88-0
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863329-66-2
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1190307-88-0
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1190307-88-0
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