| Identification | More | [Name]
Orthoboric acid | [CAS]
10043-35-3 | [Synonyms]
EZ TBE(TM) BUFFER
TBE
TBE 10X BUFFER
TBE 5X BUFFER
TBE BUFFER
TBE BUFFER DISODIUM
TRIS-BORAT-EDTA PUFFER
TRIS-BORATE-EDTA
TRIS-BORATE-EDTA BUFFER
TRIS-BORATE-EDTA DISODIUM
Ant flip
basilitb
boric
Boric acid (BH3O3)
Boric acid (H3BO3)
boricacid(h3bo3)
Boricacid,medicinal
Borofax
Boron hydroxide
Borsaure | [EINECS(EC#)]
201-191-5 | [Molecular Formula]
BH3O3 | [MDL Number]
MFCD00236358 | [Molecular Weight]
61.83 | [MOL File]
10043-35-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Boric acid is a white, amorphous powder or
colorless, crystalline solid. | [Melting point ]
160 °C (dec.) (lit.) | [Boiling point ]
219-220 °C (9.7513 mmHg)
| [density ]
1.435 | [vapor pressure ]
2.6 mm Hg ( 20 °C)
| [storage temp. ]
Store at RT. | [solubility ]
H2O: soluble
| [form ]
working solution
| [pka]
8.91±0.43(Predicted) | [color ]
≤10(APHA)
| [Specific Gravity]
1.435 | [Odor]
Odorless | [PH]
3.6-4.4 (25℃, saturated solution in H2O) | [PH Range]
3.8 - 4.8 | [Water Solubility ]
49.5 g/L (20 ºC) | [Sensitive ]
Hygroscopic | [λmax]
λ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.05 | [Merck ]
14,1336 | [BRN ]
1697939 | [Exposure limits]
ACGIH: TWA 2 mg/m3; STEL 6 mg/m3 | [InChIKey]
KGBXLFKZBHKPEV-UHFFFAOYSA-N | [LogP]
-1.09 at 22℃ | [CAS DataBase Reference]
10043-35-3(CAS DataBase Reference) | [NIST Chemistry Reference]
| [EPA Substance Registry System]
|
| Safety Data | Back Directory | [Hazard Codes ]
Xi,T,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R60:May impair fertility.
R63:Possible risk of harm to the unborn child.
R62:Possible risk of impaired fertility. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S53:Avoid exposure-obtain special instruction before use .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S37/39:Wear suitable gloves and eye/face protection .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S22:Do not breathe dust . | [WGK Germany ]
2
| [RTECS ]
ED4550000
| [F ]
3 | [TSCA ]
Yes | [HS Code ]
28100090 | [Hazardous Substances Data]
| [Toxicity]
LD50 orally in rats: 5.14 g/kg (Smyth). |
| Hazard Information | Back Directory | [Hazard]
Toxic via ingestion. Use only weak solu-
tions. Irritant to skin in dry form.
| [Potential Exposure]
Boric acid is a fireproofing agent for
wood; a preservative, and an antiseptic. It is used in the
manufacture of glass, pottery, enamels, glazes, cosmetics,
cements, porcelain, borates, leather, carpets, hats, soaps;
artificial gems; in tanning leather; printing, dyeing, painting,
and photography. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts
the skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from
exposure, begin rescue breathing (using universal precautions,
including resuscitation mask) if breathing has
stopped and CPR if heart action has stopped. Transfer
promptly to a medical facility. When this chemical has
been swallowed, get medical attention. Give large quantities
of water and induce vomiting. Do not make an unconscious
person vomit. | [Shipping]
UN 3077 Environmentally hazardous substances,
solid, n.o.s., Hazard class: 9; Labels: 9—Miscellaneous
hazardous material, Technical Name Required. | [Incompatibilities]
Boric acid decomposes in heat above
100 C, forming boric anhydride and water. Boric acid is
hygroscopic; it will absorb moisture from the air. Boric
acid aqueous solution is a weak acid; incompatible with
strong reducing agents including alkali metals and metal
hydrides (may generate explosive hydrogen gas); acetic
anhydride, alkali carbonates, and hydroxides. Violent
reaction with powdered potassium metal, especially if
impacted. Attacks iron in the presence of moisture. | [Chemical Properties]
Boric acid is a white, amorphous powder or
colorless, crystalline solid. | [Chemical Properties]
Boric acid occurs as a hygroscopic, white crystalline powder,
colorless shiny plates, or white crystals. | [Chemical Properties]
White powder or granules and odorless. It is incompatible with potassium, acetic anhydride, alkalis, carbonates, and hydroxides. Boric acid has uses in the production of textile fiberglass, flat panel displays, and eye drops. Boric acid is recognized for its application as a pH buffer and as a moderate antiseptic agent and emulsifier.
| [Waste Disposal]
Boric acids may be recovered
from organic process wastes as an alternative to disposal. | [Physical properties]
Colorless, transparent triclinic crystal or white granule or powder; density 1.435 g/cm3; melts at 171°C under normal heating; however, slow heating causes loss of water; sparingly soluble in cold water (4.7% at 20°C); pH of 0.1M solution 5.1; readily dissolves in hot water (19.1% at 80°C and 27.5% at 100°C); also soluble in lower alcohols and moderately soluble in pyridine. | [Uses]
For weatherproofing wood and fireproofing fabrics; as a preservative; manufacture of cements, crockery, porcelain, enamels, glass, borates, leather, carpets, hats, soaps, artificial gems; in nickeling baths; cosmetics; printing and dyeing, painting; photography; for impregnating wicks; electric condensers; hardening steel. Also used as insecticide for cockroaches and black carpet beetles. | [Definition]
ChEBI: Boric acid is a member of boric acids. It has a role as an astringent. It is a conjugate acid of a dihydrogenborate. | [Preparation]
Boric acid is produced from borax, colemanite, or other inorganic borates by reaction with sulfuric acid or hydrochloric acid, and cooling the solution to proper temperature:
Na2B4O7 ? 10Η2Ο + H2SO4 → 4H3BO3 + Na2SO4 + 5H2O
It also may be prepared by extraction of weak borax brine with a kerosene solution of an aromatic diol, such as 2-ethyl-1,3-hexanediol or 3-chloro- 2-hydroxy-5-(1,1,3,3-tetramethylbutyl)benzyl alcohol. The diol-borate chelate formed separates into a kerosene phase. Treatment with sulfuric acid yields boric acid which partitions into aqueous phase and is purified by recrystallization. | [Production Methods]
Boric acid occurs naturally as the mineral sassolite. However, the
majority of boric acid is produced by reacting inorganic borates
with sulfuric acid in an aqueous medium. Sodium borate and
partially refined calcium borate (colemanite) are the principal raw
materials. When boric acid is made from colemanite, the fineground
ore is vigorously stirred with mother liquor and sulfuric acid
at about 908℃. The by-product calcium sulfate is removed by
filtration, and the boric acid is crystallized by cooling the filtrate. | [Brand name]
Alpagelle;Anojel;Anugard;Anojel;Anugard;Anusol hc;Anusol hc;Berlicetin;Betadrin;Berlicetin;Betadrin;Bluboro;Boroformal;Bluboro;Boroformal;Borogal;Borogal;Borsyre viskos;Cacimag;Borsyre viskos;Cacimag;Caclcifor;Caclcifor;Calcamyl-24;Calcibenzamin;Calcamyl-24;Calcibenzamin;Camilca;Camilca;Chibro;Coneolent;Chibro;Coneolent;Cutaden;Cutaden;Dissol;Ear-dry;Dissol;Ear-dry;Egosol-bs;Egosol-bs;Evercil;Fermakzem;Evercil;Fermakzem;Flex-care;Flex-care;Glaucadrine;Glucocalcium;Glaucadrine;Glucocalcium;Kalopsisi;Kerapos;Kalopsisi;Kerapos;Kodomo smarin;Kodomo smarin;Komex;Lindemil;Komex;Lindemil;Macaldex;Macaldex;Mentol sedans sulfamidad;Neo-smarin dia;Mentol sedans sulfamidad;Neo-smarin dia;Neo-vagipurin;Neo-vagipurin;Normol;O-biol;Normol;O-biol;Oestro-gynedron;Oestro-gynedron;Ophtalmin;Otocaina;Ophtalmin;Otocaina;Pedoz;Pedoz;Phoscanol;Phoscanol;Poly-gynedron;Preferal;Poly-gynedron;Preferal;Proculin;Proculin;Rhinophenazol;Saddle mate;Rhinophenazol;Saddle mate;Swim-ear;Swim-ear;Swim-eye;Swim-eye;Timazincum;Timazincum;Tipolin;Tricho-gynedron;Tipolin;Tricho-gynedron;Unisol;Unisol;Vetacalin-m;Alpagelle;Vetacalin-m. | [World Health Organization (WHO)]
Boric acid and some borates were formerly extensively used as
disinfectants and antiinflammatory agents. By the late 1960s an association between
the death of many infants and application of high concentrations of boric acid
contained in topical preparations used in the treatment of napkin rash had been
established. This led to the restriction of the use of boric acid in pharmaceutical
preparations by many regulatory authorities. In some countries it is now permitted
only as an ingredient in ophthalmological preparations. | [General Description]
Boric acid is a weak monobasic acid, it accepts OH- ions, hence is a Lewis acid. In boric acid, B is sp2 hybridized, forming a planar triangle structure. The principal oxide of boron, B2O3, is obtained as a vitreous solid by dehydration of boric acid at red heat. | [Flammability and Explosibility]
Nonflammable | [Pharmaceutical Applications]
Boric acid is used as an antimicrobial preservative in eye drops,
cosmetic products, ointments, and topical creams. It is also used as
an antimicrobial preservative in foods.
Boric acid and borate have good buffering capacity and are used
to control pH; they have been used for this purpose in external
preparations such as eye drops.
Boric acid has also been used therapeutically in the form of
suppositories to treat yeast infections. In dilute concentrations it
is used as a mild antiseptic, with weak bacteriostatic and fungistatic
properties, although it has generally been superseded by more
effective and less toxic disinfectants. | [Biochem/physiol Actions]
Boric acid has antibacterial and fungicidal properties. It is used in the periodontal therapy as an irrigation solution as it elicits bactericidal effects in microbial biofilms in root canal. Boric acid may favor osteoblastic activity and inhibit bone loss. It inhibits Candida albicans fungal infection and has potential to treat vaginal infection. | [Safety]
Boric acid is a weak bacteriostatic and antimicrobial agent, and has
been used in topical preparations such as eye lotions, mouthwashes
and gargles. It has also been used in US- and Japanese-approved
intravenous products. Solutions of boric acid were formerly used to
wash out body cavities, and as applications to wounds and ulcers,
although the use of boric acid for these purposes is now regarded as
inadvisable owing to the possibility of absorption. Boric acid is
not used internally owing to its toxicity. It is poisonous by ingestion
and moderately toxic by skin contact. Experimentally it has proved
to be toxic by inhalation and subcutaneous routes, and moderately
toxic by intraperitoneal and intravenous routes.
Boric acid is absorbed from the gastrointestinal tract and from
damaged skin, wounds, and mucous membranes, although it does
not readily permeate intact skin. The main symptoms of boric acid
poisoning are abdominal pain, diarrhea, erythematous rash
involving both skin and mucous membrane, and vomiting. These
symptoms may be followed by desquamation, and stimulation or
depression of the central nervous system. Convulsions, hyperpyrexia,
and renal tubular damage have been known to occur.
Death has occurred from ingestion of less than 5 g in young
children, and of 5–20 g in adults. Fatalities have occurred most
frequently in young children after the accidental ingestion of
solutions of boric acid, or after the application of boric acid powder
to abraded skin.
The permissible exposure limit (PEL) of boric acid is 15 mg/m3
total dust, and 5 mg/m3 respirable fraction for nuisance dusts.
LdLo (man, oral): 429 mg/kg
LdLo (woman, oral): 200 mg/kg
LdLo (infant, oral): 934 mg/kg
LdLo (man, skin): 2.43 g/kg
LdLo (infant, skin): 1.20 g/kg
LD50 (mouse, oral): 3.45 g/kg
LD50 (mouse, IV): 1.24 g/kg
LD50 (mouse, SC): 1.74 g/kg
LD50 (rat, oral): 2.660 g/kg
LD50 (rat, IV): 1.33 g/kg
LD50 (rat, SC): 1.4 g/kg | [storage]
Boric acid is hygroscopic and should therefore be stored in an airtight,
sealed container. The container must be labeled ‘Not for
Internal Use’. | [Purification Methods]
Crystallise the acid three times from H2O (3mL/g) between 100o and 0o, after filtering through sintered glass.Dry it to constant weight over metaboric acid in a desiccator. It is steam volatile. After two recrystallisations of ACS grade. it had Ag at 0.2 ppm. Its solubility (%) in H2O is 2.66 at 0o, 4.0 at 12o and 24 at 80o. At 100o it loses H2O to form metaboric acid (HBO2). When it is heated to redness or slowly to 200o, or over P2O5 in vacuo, it dehydrates to boric anhydride (B2O3) [1303-82-6] to give a white hard glass or crystals with m ~294o.The glass softens on heating and liquefies at red heat. It is an astringent, a fungicide and an antibacterial.
[McCulloch J Am Chem Soc 59 2650 1937, Kelly J Am Chem Soc 63 1137 1941, Taylor & Cole J Chem Soc 70 1926, Conti J Soc Chem Ind 44 343T 1925.] | [Regulatory Status]
Accepted for use as a food additive in Europe. Included in the FDA
Inactive Ingredients Database (IV injections; ophthalmic preparations;
(auricular) otic solutions; topical preparations). Reported in
the EPA TSCA Inventory. In the UK, the use of boric acid in
cosmetics and toiletries is restricted. Included in the Canadian List
of Acceptable Non-medicinal Ingredients. |
| Questions And Answer | Back Directory | [Description]
Boric acid (orthoboric acid) is a weakly acidic hydrate of boric oxide with mild antiseptic, antifungal, and antiviral properties.
Boric acid can be used to treat yeast infections and acne, for eyewash by treating any bacterial infection and soothing inflamed eyes, and as a cleanser, deodorizer, stain remover, disinfectant and mold killer. Boric acid can be used as a pesticide to control a variety of pests, as a fungicide for citrus, and as an herbicide along rights-of-way. Boric acid can be used for the manufacture of textile fiberglass, household glass products and the glass used in LCD displays, to reinforce plastics in various products (boats, computer circuit boards and pipes), as a flame retardant, and as a pH buffer agent in plating.
| [References]
[1] //npic.orst.edu
[2] //www.polyu.edu.hk
[3] Zenat A. Nagieb, Mona A. Nassar, Magda G. El-Meligy (2011) Effect of Addition of Boric Acid and Borax on Fire-Retardant and Mechanical Properties of Urea Formaldehyde Saw Dust Composites, International Journal of Carbonhydrate Chemistry, 2011, 146763
[4] //www.boricacid.net.au/uses-of-boric-acid
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