ChemicalBook >> CAS DataBase List >>(Z)-Guggulsterone
(Z)-Guggulsterone
- CAS No.
- 39025-23-5
- Chemical Name:
- (Z)-Guggulsterone
- Synonyms
- GUGGULSTERONE;GUGULSTERONE;GUGGULSTERONE Z;Z-Gugglesterone;GUGGULESTERONE Z;(Z)-Guggulsterone;CIS GUGGULSTERONE;GUGGULSTERONE Z(P);GUGGULSTERONE (Z FORM);Guggulsterone Z (25 mg)
- CBNumber:
- CB4309068
- Molecular Formula:
- C21H28O2
- Molecular Weight:
- 312.45
- MDL Number:
- MFCD01310757
- MOL File:
- 39025-23-5.mol
- MSDS File:
- SDS
Last updated:2024-06-30 15:45:59
| Melting point | 188-190° |
|---|---|
| alpha | D26 -61° (c = 1 in chloroform) |
| Boiling point | 463.3±45.0 °C(Predicted) |
| Density | 1.10±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 5 mg/mL |
| form | powder |
| color | light yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChIKey | WDXRGPWQVHZTQJ-OSJVMJFVSA-N |
| LogP | 3.650 (est) |
| EWG's Food Scores | |
| FDA UNII |
(Z)-Guggulsterone price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1302214 | Guggulsterone Z United States Pharmacopeia (USP) Reference Standard | 39025-23-5 | 25mg | $489 | 2025-03-01 | Buy |
| Sigma-Aldrich | 78251 | (Z)-Guggulsterone analytical standard | 39025-23-5 | 10mg | $283 | 2023-05-15 | Buy |
| Cayman Chemical | 71800 | (Z)-Guggulsterone | 39025-23-5 | 5mg | $109 | 2025-03-01 | Buy |
| Cayman Chemical | 71800 | (Z)-Guggulsterone | 39025-23-5 | 50mg | $849 | 2025-03-01 | Buy |
| Sigma-Aldrich | G5168 | (Z)-Guggulsterone ≥89% (HPLC), powder | 39025-23-5 | 5mg | $208 | 2025-03-01 | Buy |
(Z)-Guggulsterone Chemical Properties,Uses,Production
Description
Guggulsterone-(Z) (39025-23-5) is a natural steroid from?Commiphora mukul?extract (guggulipid) which lowers cholesterol and acts as an FXR antagonist.1?Attenuates astrocyte-mediated neuroinflammation.2? Induces differentiation of pluripotent stem cells to dopaminergic neurons.3 Produces antidepressant-like effects via activation of the BDNF signaling pathway in mouse models.4Uses
(Z)-Guggulsterone acts as an α-glucosidase inhibitor also known as a hypolipidemic agent.Uses
Z-Guggulsterone acts as an α-glucosidase inhibitor also known as a hypolipidemic agent.Definition
ChEBI: Guggulsterone is a 3-hydroxy steroid. It has a role as an androgen.Biological Activity
Broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (K i values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (K i = 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signalling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo . More active isomer of Guggulsterone (Pregna-4,17(20)-diene-3,16-dione ).Biochem/physiol Actions
(Z)-Guggulsterone is a natural product that lowers cholesterol due to its function as an antagonist ligand for the bile acid receptor. (Z)-Guggulsterone is a nuclear hormone receptor that regulates the transcription of several genes involved in cholesterol metabolism and plays a role in cholesterol level regulation. (Z)-Guggulsterone is also a selective farnesoid X receptor (FXR) modulator.storage
Store at RTReferences
1) Urizar?et al.?(2002),?A Natural Product That Lowers Cholesterol as an Antagonist Ligand for FXR; Science,?296?1703 2) Liu?et al.?(2018),?Z-Guggulsterone attenuates astrocytes-mediated neuroinflammation after ischemia by inhibiting toll-like receptor 4 pathway; J. Neurochem.,?147?803 3) Agbay?et al.?(2018),?Guggulsterone-releasing Microspheres Direct the Differentiation of Human Induced Pluripotent Stem Cells Into Neural Phenotypes; Biomed. Mater.,?13?034104 4) Liu?et al.?(2017),?Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway; Int. J. Neuropsychopharmacol.,?20?485(Z)-Guggulsterone Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 133)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
View Lastest Price from (Z)-Guggulsterone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-28 | (Z)-Guggulsterone
39025-23-5
|
US $0.00 / MG | 20MG | 99% HPLC | 100KG | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2025-04-10 | (Z)-Guggulsterone
39025-23-5
|
US $0.00 / kg | 1kg | 98% | 200kg | Shanghai Joiny Pharmaceutical Co.,LTD | |
 |
2020-07-06 | (E)-Guggulsterone
39025-23-5
|
US $1.00 / KG | 1g | 99% | 100KG | Career Henan Chemical Co |
-
- (Z)-Guggulsterone
39025-23-5
- US $0.00 / MG
- 99% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- (Z)-Guggulsterone
39025-23-5
- US $0.00 / kg
- 98%
- Shanghai Joiny Pharmaceutical Co.,LTD
-
- (E)-Guggulsterone
39025-23-5
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
39025-23-5((Z)-Guggulsterone)Related Search:
1of4
4,17(20)-(CIS)-PREGNADIEN-3,16-DIONE
GUGULSTERONE
GUGGULESTERONE Z
GUGGULSTERONE Z
GUGGULSTERONE (Z FORM)
CIS-4,17(20)-PREGNADIENE-3,16-DIONE
CIS GUGGULSTERONE
PREGNA-4,17(20)-DIENE-3,16-DIONE
(17Z)-Pregna-4,17(20)-diene-3,16-dione
(Z)-Guggulsterone
(17Z)-Pregna-4,17(20)-diene-3,16-dione, 4,17(20)-cis-Pregnadiene-3,16-dione
Z-Gugglesterone
GUGGULSTERONE Z(P)
(Z)-Pregna-4,17(20)-diene-3,16-dione
Guggulsterone Z (25 mg)
Pregna-4,17(20)-diene-3,16-dione, (17Z)-
Z-Guggulsterone Z-Guggulsterone HPLC≥90% 39025-23-5 5mg
GUGGULSTERONE
(8R,9S,10R,13S,14S,Z)-17-ethylidene-10,13-dimethyl-7,8,9,10,11,12,13,14,15,17-decahydro-1H-cyclopenta[a]phenanthrene-3,16(2H,6H)-dione
39025-23-5
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