ChemicalBook >> CAS DataBase List >>COMBRETASTATIN A-4
COMBRETASTATIN A-4
- CAS No.
- 117048-59-6
- Chemical Name:
- COMBRETASTATIN A-4
- Synonyms
- CA4;CS-A4;CS-284;CRC 87-09;NSC 817373;NSC-817373;Combrestatin A4;CoMbretastatin A;Combretastatin A4;(Z)-CombretastatinA4
- CBNumber:
- CB9496826
- Molecular Formula:
- C18H20O5
- Molecular Weight:
- 316.35
- MDL Number:
- MFCD03453309
- MOL File:
- 117048-59-6.mol
- MSDS File:
- SDS
Last updated:2024-06-08 09:01:56
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331-H318 | |||||||||
| Precautionary statements | P261-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 23/24/25-41 | |||||||||
| Safety Statements | 26-36/37-39-45 | |||||||||
| RIDADR | UN 2811 | |||||||||
| WGK Germany | 2 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29095000 | |||||||||
| NFPA 704 |
|
COMBRETASTATIN A-4 price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C7744 | Combretastatin A4 ≥98% (HPLC), powder | 117048-59-6 | 5mg | $70.2 | 2025-03-01 | Buy |
| Sigma-Aldrich | 234200 | Combretastatin A-4 | 117048-59-6 | 10mg | $230 | 2025-03-01 | Buy |
| TCI Chemical | C2520 | Combretastatin A4 >98.0%(HPLC) | 117048-59-6 | 25mg | $135 | 2025-03-01 | Buy |
| TCI Chemical | C2520 | Combretastatin A4 >98.0%(HPLC) | 117048-59-6 | 250mg | $812 | 2025-03-01 | Buy |
| Cayman Chemical | 10007412 | Combrestatin A4 ≥98% | 117048-59-6 | 5mg | $63 | 2025-03-01 | Buy |
COMBRETASTATIN A-4 Chemical Properties,Uses,Production
Description
Combrestatin A4 (CA4) is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. Combrestatin A4 was shown to inhibit tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-
Chemical Properties
Crystalline PowderUses
Combretastatin A4 has been used:
- as an anti-tubulin agent to determine the effects of isocitrate dehydrogenases (IDH1 and IDH2) proteins in G2/M phase
- to evaluate the anti-proliferative and pro-apoptotic properties of biphenyl CA4 derivatives in both 2D and 3D cancerous and non-cancerous cell models
- as a microtubule inhibitor to study its effects on motility of Ascaris suum L3 larvae
Uses
Combretastatin is a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. A potent cytotoxic agent which strongly inhibits the polymerization of tubulin by binding to the colchicine site.Definition
ChEBI: Combretastatin A4 is a stilbenoid.General Description
Combretastatin A4 belong to the class of colchicinoids compounds.Biological Activity
Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo . Acts by inhibiting tubulin polymerization (IC 50 = 2-3 μ M).Biochem/physiol Actions
Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis. It inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. It has antitumor activity by inhibiting AKT function in human gastric cells. The inhibited AKT activation causes decreased cell proliferation, cell cycle arrest, and reduced in vitro migration/invasiveness and in vivo metastatic ability. Combretastatin A4 is a natural stilbenoid phenol.Anticancer Research
It is a stilbenoid compound and the active among all combretastatins isolated fromthe bark of Combretum caffrum and is used for colon, lung, and leukemia cancertherapy (Shoeb 2006).COMBRETASTATIN A-4 Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Global( 281)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
View Lastest Price from COMBRETASTATIN A-4 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-03-28 | Combretastatin A4
117048-59-6
|
US $0.00 / kg | 25kg | 98% | Inquiry | PNP Biotech Co. Ltd | |
 |
2023-02-14 | Combretastatin A4 117048-59-6
117048-59-6
|
US $17.00 / mg | 20mg | ≥98% | 1000.00 kgs | NanJing Spring & Autumn Biological Engineering CO., LTD. | |
 |
2022-11-02 | Combretastatin A4
117048-59-6
|
US $390.00 / g | 1g | 99% | 1kg | Baoji Guokang Healthchem co.,ltd |
-
- Combretastatin A4
117048-59-6
- US $0.00 / kg
- 98%
- PNP Biotech Co. Ltd
-
- Combretastatin A4 117048-59-6
117048-59-6
- US $17.00 / mg
- ≥98%
- NanJing Spring & Autumn Biological Engineering CO., LTD.
-
- Combretastatin A4
117048-59-6
- US $390.00 / g
- 99%
- Baoji Guokang Healthchem co.,ltd
117048-59-6(COMBRETASTATIN A-4)Related Search:
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MOSLOFLAVONE
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4-Hydroxyphenethyl alcohol
1of4
(Z)-2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]phenol,3,4,5-Trimethoxy-3hydroxy-4methoxy-(Z)-stilbene,CS-A4
Combrestatin A4( 2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol )
(Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol ,98%
2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
3-[(Z)-2-(3,4,5-Trimethoxyphenyl)ethenyl]-6-methoxyphenol
5-[(Z)-2-(3,4,5-Trimethoxyphenyl)ethenyl]-2-methoxyphenol
Combretastatin A4
(Z)-CombretastatinA4
combretastatin A-4 (CA-4)
2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
Combrestatin A4
(Z)-2-Methoxy-5-[2-(3,4,5-triMethoxyphenyl)ethenyl]phenol, 3,4,5-TriMethoxy-3'-hydroxy-4'-Methoxy-(Z)-stilbene
CS-A4
CoMbretastatin A
CA-4, Combretastatin A-4
1-(3,4,5-Trimethoxyphenyl)-2-(3′-hydroxy-4′-methoxyphenyl) ethane 3,4,5-trimethoxy-3′-hydroxy-4′-methoxystilbene
CA4
(Z)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenol
2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol
(Z)-2-Methoxy-5-(3,4,5-Trimethoxystyryl)Phenol
Combretastatin A4 117048-59-6
Combretastatin A-4 - CAS 117048-59-6 - Calbiochem
CS-284
CRC 87-09
2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol, Z
Combretastatin A4 (CRC 87-09)
Combretastatin A4 >
Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-
Recombinant Human Carbonic Anhydrase IV/CA4 Protein, His Tag
3'-Hydroxy-3,4,4',5-tetramethoxy-cis-stilbene
Combretastatin TXB-4
NSC 817373
NSC-817373
117048-59-6
17048-59-6
Inhibitors
Combretastatin
API
Anti-cancer & immunity