이소프로필알코올 속성

이소프로필알코올 C화학적 특성, 용도, 생산

물성

Iso-Propyl Alcohol (IPA) 2-Propanol, sec-Propyl alcohol, 이소 프로필 알코올, 이소프로판올 다른 이름; 강한 냄새가 나는 무색의 가연성 화합물입니다. 그것은 1- 프로판올의 구조 이성질체이다. 대다수의 IPA는 코팅 또는 산업 공정 용 용매로 사용되었습니다.

개요

아이소프로필 알코올(isopropyl alcohol) 또는 프로판-2-올(propan-2-ol), 2-프로판올(2-propanol)은 분자식 C3H8O의 화학 약품으로, 무색이며, 인화성을 가지는 약품이다. 무극성 물질을 용해하며 자기 얼룩을 남기지 않고 쉽게 증발하는 특징이 있어 반도체, LCD 등 IT 부품 세정액으로 많이 활용되며, 페인트, 잉크 등의 용제로도 사용되는 강한 알콜향의 무색 유기 용제이다.

용도

이소 프로필 알코올 (Iso-Propyl Alcohol, IPA)은 화장품, 피부 및 모발 준비 용품, 의약품, 향수, 래커 제형, 염료 용액, 부동액, 비누, 창문 세척제의 소비자 용도로 주로 제조됩니다. 산업 응용 분야는 접착제 및 실란트 화학 물질, 비 살충 농약, 연료 및 연료 첨가제, 중간체, 윤활제, 페인트 및 코팅 첨가제, 석유 생산 관련 프로세스 조정자 및 보조 장치 및 세척 또는 탈지 용 세정제를 포함합니다.

제품 소개

이소 프로필 알코올 (Iso-Propyl Alcohol, IPA)은 화장품, 피부 및 모발 준비 용품, 의약품, 향수, 래커 제형, 염료 용액, 부동액, 비누, 창문 세척제의 소비자 용도로 주로 제조됩니다. 

순도시험

  (1) 용해도 : 이 품목 10mL를 물 40mL에 혼합한 다음 1시간 후 이 액은 동량의 물처럼 맑아야 한다.  (2) 산도(초산으로서) : 물 100mL에 페놀프탈레인시액 2방울을 가하고 적어도 30초간 엷은 홍색을 지속할 때까지 0.01N 수산화나트륨용액을 가한 다음 이 품목 50mL(약 39g에 해당하는 양)를 넣어 섞는다. 다시 엷은 홍색이 나타날 때까지 0.01N 수산화나트륨용액으로 적정할 때, 그 소비량은 0.7mL 이하이어야 한다.  (3) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 1.0ppm 이하이어야 한다.  (4) 증류시험 : 이 품목은 비점 및 유분측정법에 따라 유분을 측정할 때, 81.3～83.3℃에서 95%(v/v) 이상을 유출하여야 한다.  (5) 증발잔류물 : 이 품목 125mL(약 100g에 해당하는 양)를 수욕상에서 증발건고하고 105℃에서 30분간 건조할 때, 그 양은 10ppm 이하이어야 한다.  (6) 과망간산염을 환원하는 물질 : 이 품목 50mL를 마개가 있는 50mL 실린더에 넣고 0.1N 과망간산칼륨용액 0.25mL를 가한 다음 10분간 방치할 때, 엷은 적색이 완전히 사라져서는 아니 된다.  (7) 비중 : 이 품목의 비중은 0.784～0.788이어야 한다.

  (8) 굴절률 : 이 품목의 굴절률 은 1.374～1.380이어야 한다.

확인시험

  이 품목 2mL에 물 3mL와 황산제이수은시액 1mL를 가하여 따뜻하게 할 때, 백～황색의 침전이 생긴다.

정량법

  이 품목 약 500mg을 정밀히 달은 다음 물을 가하여 50mL로 하고 이 액 10mL를 취하여 물을 가하여 100mL로 한 것을 시험원액으로 한다. 따로 이소프로필알콜표준품 약 500mg을 정밀히 달아 시험원액과 동일하게 희석한 것을 표준원액으로 한다. 시험원액 4mL 및 표준원액 4mL를 100mL 메스플라스크에 각각 취한 다음 각 플라스크에 내부표준용액(tert-부틸알콜 약 500mg을 정밀히 달은 다음 물을 가하여 50mL로 하고 이 액 10mL를 취하여 물을 가하여 100mL로 한 액) 4mL를 정확히 취하고 이에 물을 가하고 100mL로 한 것을 시험용액 및 표준용액으로 한다. 시험용액 1μL 및 표준용액 1μL를 각각 가스크로마토그래피에 주입하고 다음 계산식에 따라 이소프로필알콜의 함량(%)을 구한다.

W_S : 이소프로필알콜표준품의 무게(mg)

W_U : 검체의 무게(mg)

R_U : 시험용액중의 tert-부틸알콜의 피크면적에 대한 이소프로필알콜 피크면적 비

R_S : 표준용액중의 tert-부틸알콜의 피크면적에 대한 이소프로필알콜 피크면적 비

    조작조건      칼      럼 : 내경 2mm, 길이 2m의 유리관 또는 스테인레스관      칼럼충전제 : 크로모소브 W—HP에 3% OV—225를 입힌 것      검  출  기 : 수소염이온화검출기(FID)      주입구온도 : 250℃      칼럼온도 : 200℃      검출기온도 : 250℃      캐리어가스 및 유량 : 질소, 30mL/min

개요

Isopropanol is a clear, colorless alcohol that is used in the production of acetone and as a solvent in the manufacture of various industrial and commercial products. It is used by the public for a number of different purposes and is commonly known as rubbing alcohol. It is flammable and miscible with both water and many different organic solvents. Isopropanol can be prepared via three different methods: indirect hydration of propylene (the ‘strong acid’ method), direct hydration of propylene, and catalytic hydrogenation of acetone.

화학적 성질

Isopropyl alcohol is a clear, colorless, mobile, volatile, flammable liquid with a characteristic, spirituous odor resembling that of a mixture of ethanol and acetone; it has a slightly bitter taste.It is miscible with water, ethyl ether, and ethyl alcohol. Isopropyl alcohol is incompatible with strong oxidizers, acetaldehyde, chlorine, ethylene oxide, acids, and isocyanates.

출처

Reported found in apple and cognac aromas (esterified). Also found in apple, banana, grapefruit and lime juice, melon, papaya, pear, onion, peas, rutabaga, tomato, wheat bread, cheeses, milk, boiled egg, cooked beef, pork and mutton, hop oil beer, rum, cocoa, coffee, scotch whiskey, grape wines, peanut, pecan, soybean, honey, beans, plum brandy, walnut, crab, clam, prickly pear and clary sage.

제조 방법

Isopropyl alcohol may be prepared from propylene; by the catalytic reduction of acetone, or by fermentation of certain carbohydrates.

정의

ChEBI: Isopropyl Alcohol is a secondary alcohol that is propane in which one of the hydrogens attached to the central carbon is substituted by a hydroxy group. It is an isomer of propyl alcohol with antibacterial properties.

주요 응용

Isopropyl Alcohol is used in a variety of applications including as a solvent for industrial processes and coating; as a component in cleaning, car care and deicing products; as a wetting agent for printing inks and as a feedstock in the manufacture of ester and Mogas/Luboil additives.
isopropyl alcohol is a carrier, anti-bacterial, and solvent for skin care lotions. Isopropyl alcohol is made from propylene, a petroleum derivative.
When compared to ethanol, 50% less is required for nucleic acid precipitation, thus minimizing the total volume to be centrifuged for DNA or RNA recovery.
Isopropyl alcohol 70% is used as an ingredient in alcohol swabs and alcohol wipes for wound cleaning, it is found in hand sanitizers, and in ear drops to prevent swimmer's ear.

일반 설명

Volatile, colorless liquid with a sharp musty odor like rubbing alcohol. Flash point of 53°F. Vapors are heavier than air and mildly irritating to the eyes, nose, and throat. Density approximately 6.5 lb / gal. Used in making cosmetics, skin and hair preparations, pharmaceuticals, perfumes, lacquer formulations, dye solutions, antifreezes, soaps, window cleaners. Sold in 70% aqueous solution as rubbing alcohol.

공기와 물의 반응

Highly flammable. Water soluble.

반응 프로필

Isopropyl Alcohol can react with AIR and OXYGEN over time to form unstable peroxides that can explode. Contact with 2-butanone increases the rate of peroxide formation. An explosive reaction occurs when Isopropanol is heated with (aluminum isopropoxide + crotonaldehyde). Forms explosive mixtures with trinitromethane and hydrogen peroxide. Reacts with barium perchlorate to form a highly explosive compound. Ignites on contact with dioxygenyl tetrafluoroborate, chromium trioxide and potassium-tert-butoxide. Vigorous reactions occur with (hydrogen + palladium), nitroform, oleum, COCl2, aluminum triisopropoxide and oxidizing agents. Reacts explosively with phosgene in the presence of iron salts. Incompatible with acids, acid anhydrides, halogens and aluminum . Isopropanol can react with PCl3, forming toxic HCl gas. (Logsdon, John E., Richard A. Loke., sopropyl Alcohol. Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons, Inc. 1996.).

건강위험

Exposures to isopropyl alcohol cause irritation to the eyes and mucous membranes. Exposures to isopropyl alcohol for 3–5 min (400 ppm) caused mild irritation of the eyes, nose, and throat, and at 800 ppm these symptoms became severe. Ingestion or an oral dose of 25 mL in 100 mL of water produced hypotension, facial flushing, bradycardia, and dizziness. Ingestion in large quantities caused extensive hemorrhagic tracheobronchitis, bronchopneumonia, and hemorrhagic pulmonary edema. Prolonged skin contact with isopropyl alcohol caused eczema and sensitivity. Delayed dermal absorption is attributed to a number of pediatric poisonings that have occurred following repeated or prolonged sponge bathing with isopropyl alcohol to reduce fever. In several cases, symptoms included respiratory distress, stupor, and coma. Laboratory animals exposed to isopropyl alcohol develop poisoning with symptoms of hind leg paralysis, unsteadiness, lack of muscular coordination, respiratory depression, and stupor. Isopropyl alcohol is a potent CNS depressant, and in large doses causes cardiovascular depression.

화재위험

Isopropyl Alcohol(IPA) is highly flammable in its liquid and vapor forms and flammable atmospheres can be created at temperatures as low as 540°F /120℃ . This means that any environment where IPA is being used needs to be well ventilated. It should be kept away from heat and open flame. As the vapour is heavier than air, it may spread along the ground, so care needs to be taken that the vapour is not ignited by a distant source.

Pharmaceutical Applications

Isopropyl alcohol (propan-2-ol) is used in cosmetics and pharmaceutical formulations, primarily as a solvent in topical formulations.( It is not recommended for oral use owing to its toxicity.
Although it is used in lotions, the marked degreasing properties of isopropyl alcohol may limit its usefulness in preparations used repeatedly. Isopropyl alcohol is also used as a solvent both for tablet film-coating and for tablet granulation, where the isopropyl alcohol is subsequently removed by evaporation. It has also been shown to significantly increase the skin permeability of nimesulide from carbomer 934.
Isopropyl alcohol has some antimicrobial activity and a 70% v/v aqueous solution is used as a topical disinfectant. Therapeutically, isopropyl alcohol has been investigated for the treatment of postoperative nausea or vomiting.

Carcinogenicity

CD-1 mice were exposed by inhalation to 0, 500, 2500, or 5000 ppm of isopropanol vapor for 6 h/day, 5 days/week for 18 months. An additional group of mice (all exposure levels) were assigned to a recovery group that were exposed to isopropanol for 12 months and then retained until study termination at 18 months. There was no increased frequency of neoplastic lesions in any of the isopropanol-exposed animals. Nonneoplastic lesions were limited to the testes (males) and the kidney. In the testes, enlargement of the seminal vesicles occurred in the absence of associated inflammatory or degenerative changes. The kidney effects included tubular proteinosis and/or tubular dilatation. The incidence of testicular and kidney effects was not increased in the isopropanol-exposed recovery animals.

환경귀착

The vast majority of isopropanol in the environment originates from manufacturing processes. Small amounts are produced by certain microbes, fungi, and yeast. The high volatility of isopropanol ensures that when it is released into the environment in any state, it eventually ends up in the atmosphere. There, it can be degraded by hydroxyl radicals or it can return to soil or water through precipitation. Its half-life in the environment is approximately 3.2 days and is highly biodegradable; bioaccumulation in plants and animals does not occur.

저장

Isopropyl alcohol should be stored in a cool, dry, well-ventilated area in tightly sealed containers with a proper label. Outside or detached storage is preferable. Inside storage should be a flammable liquids storage room or cabinet. Workers should not store isopropyl alcohol above 37°C (100°F). Containers of isopropyl alcohol should be protected from physical damage and contact with air, and should be stored separately from strong oxidizers, acetaldehyde, chlorine, ethylene oxide, acids, and isocyanates. Isopropyl alcohol should be transported to the nearest laboratory as quickly as possible in cool containers.

비 호환성

Incompatible with oxidizing agents such as hydrogen peroxide and nitric acid, which cause decomposition. Isopropyl alcohol may be salted out from aqueous mixtures by the addition of sodium chloride, sodium sulfate, and other salts, or by the addition of sodium hydroxide.

주의 사항

Workers should wash hands and face thoroughly after handling isopropyl alcohol. Workers should wear gloves, safety glasses and a face shield, boots, apron, and a full impermeable suit is recommended if exposure is possible to a large portion of the body.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral capsules, tablets, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

이소프로필알코올 준비 용품 및 원자재

원자재

준비 용품

이소프로필알코올 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shandong Yanshuo Chemical Co., Ltd.	+86-18678179670 +86-18615116763	sales@yanshuochem.com	China	101	58
Qingdao Trust Agri Chemical Co.,Ltd	+8613573296305	aroma@qdtrustagri.com	China	165	58
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	9602	58
Hebei Duling International Trade Co. LTD	+8618032673083	sales05@hbduling.cn	China	15753	58
Deoksan General Science Co., Ltd	+82-02-957-3792 +82-02-957-3792	dscsi@hanmail.net	South Korea	4	58
PT CHEM GROUP LIMITED	+86-85511178 +86-85511178	peter68@ptchemgroup.com	China	35453	58
Hebei Yime New Material Technology Co., Ltd.	+86-66697723 +86-17703311139	admin@china-yime.com	China	563	58
Hong Kong Excellence Biotechnology Co., Ltd.	+86-86-18838029171 +8618126314766	ada@sh-teruiop.com	China	892	58
Hebei Jingbo New Material Technology Co., Ltd	+8619931165850	hbjbtech@163.com	China	1000	58
Sigma Audley	+86-18336680971 +86-18126314766	nova@sh-teruiop.com	China	524	58

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