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| | 6-Aminopenicillanic acid Basic information |
| | 6-Aminopenicillanic acid Chemical Properties |
| Melting point | 198-200 °C (dec.)(lit.) | | alpha | 276.3 º (c=1.2, 0.1N HCl 22 ºC) | | Boiling point | 460.2±45.0 °C(Predicted) | | density | 1.3418 (rough estimate) | | refractive index | 1.6300 (estimate) | | storage temp. | 2-8°C | | solubility | 2.46g/l | | form | Fine Powder | | pka | pKa 2.3 (Uncertain) | | color | White to cream | | PH | 3.4 (100g/l, H2O) | | optical activity | [α]22/D +276.3°, c = 1.2 in 0.1 M HCl | | Water Solubility | Soluble in water and hydrochoric acid. | | Merck | 14,458 | | BRN | 15080 | | Stability: | Light sensitive | | InChIKey | NGHVIOIJCVXTGV-SDKNWNMFSA-N | | LogP | -3.87 at 22.5℃ | | CAS DataBase Reference | 551-16-6(CAS DataBase Reference) | | EPA Substance Registry System | |
| | 6-Aminopenicillanic acid Usage And Synthesis |
| Chemical Properties | WHITE TO CREAM FINE POWDER | | Uses | 6-Aminopenicillanic acid is the basic unit in penicillin?s, which is obtained from the fermentation brew of the Penicillium mold. It acts as a starting material for the preparation of many semisynthetic penicillins. Further, it serves as apharmaceutical intermediate. In addition to this, it is used in antibiotics research and experimental application. | | Uses | (+)-6-Aminopenicillanic Acid is the core structure in penicillins, obtained from the fermentation brew of the Penicillium mold. (+)-6-Aminopenicillanic Acid is used as the main starting block for the
preparation of numerous semisynthetic penicillins. | | Definition | ChEBI: A penicillanic acid compound having a (6R)-amino substituent. The active nucleus common to all penicillins, it may be substituted at the 6-amino position to form the semisynthetic penicillins, resulting in a variety of antibacterial and ph
rmacologic characteristics. | | General Description | Chemical structure: ?-lactam | | Flammability and Explosibility | Non flammable | | Safety Profile | Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of NOx and SOx. | | Purification Methods | This acid crystallises from water. [Kleppe & Stroninger J Biol Chem 254 4856 1979,Beilstein 27 III/IV 2858.] |
| | 6-Aminopenicillanic acid Preparation Products And Raw materials |
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