|
|
| | Propiverine hydrochloride Basic information |
| Product Name: | Propiverine hydrochloride | | Synonyms: | (1-methyl-3,4,5,6-tetrahydro-2h-pyridin-4-yl) 2,2-diphenyl-2-propoxy-acetate chloride;1-methyl-4-piperidyl diphenylpropoxyacetate hydrochloride;PROPIVERINE HCL;propiverine hydrochloride;PROPIVERINE HYDROCHLORRIDE;aceticacid,diphenylpropoxy-,1-methyl-4-piperidylester,hydrochloride;alpha,alpha-diphenyl-alpha-n-propoxyaceticacid1-methylpiperidyl-4-esterhyd;alpha-phenyl-alpha-propoxy-benzeneaceticaci1-methyl-4-piperidinylester | | CAS: | 54556-98-8 | | MF: | C23H30ClNO3 | | MW: | 403.94 | | EINECS: | | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Heterocycles | | Mol File: | 54556-98-8.mol |  |
| | Propiverine hydrochloride Chemical Properties |
| Melting point | 224-226°C | | storage temp. | 2-8°C | | solubility | H2O: soluble5mg/mL, clear (warmed) | | form | powder | | color | white to beige | | CAS DataBase Reference | 54556-98-8(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 37/38-41 | | Safety Statements | 26-39 | | WGK Germany | 3 | | RTECS | AH3297000 | | Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 36, 36, 22, 25 i.v.; 223, 283, 1632, 1411 s.c.; 410, 323, 1000, 1092 orally (Yamashita) |
| | Propiverine hydrochloride Usage And Synthesis |
| Description | Propiverine hydrochloride is a new urological agent developed for pollakuria and
aconuresis. It appears to exhibit anticholinergic properties and in animal experiments
inhibited KCl induced contractions in the bladder and ileum. | | Chemical Properties | Off-White Solid | | Originator | Apogepha (Germany) | | Uses | Propiverine is used in treatment of urinary incontinence. Propiverine is an anticholinergic. | | Definition | ChEBI: Propiverine hydrochloride is a diarylmethane. | | Brand name | Mictonorm; Mictonetten | | General Description | Propiverine hydrochloride drug is a tertiary amine with spasmolytic and analgesic properties. This drug exerts neurotropic and musculotropic effects on the urinary bladder and smooth muscles. Propiverine hydrochloride has a half-life of 20 hours. | | Biochem/physiol Actions | Propiverine is an antimuscarinic drug used for the treatment of overactive blaqdder and urinary incontinence. Propiverine and/or its metabolites also have calcium channel blocking properties in addition to antimuscarinic activity, which may contribute to the clinical activity. | | Clinical Use |
Treatment of urinary frequency, urgency and
incontinence
Neurogenic bladder instability | | Drug interactions | Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased risk of antimuscarinic
side effects with disopyramide. | | Metabolism | Propiverine is extensively metabolised by intestinal and
hepatic enzymes. Four metabolites were identified in
urine; two of them are pharmacologically active and may
contribute to the therapeutic efficacy.
Propiverine and its metabolites are excreted in the urine,
bile and faeces. |
| | Propiverine hydrochloride Preparation Products And Raw materials |
|